AIMC Topic: Hippo Signaling Pathway

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Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.

Cell genomics Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Animals Deep Learning Protein Binding Mice Signal Transduction Transcription Factors Protein Serine-Threonine Kinases Adaptor Proteins, Signal Transducing DNA-Binding Proteins Molecular Dynamics Simulation Phosphoproteins Trophoblasts Enhancer Elements, Genetic Muscle Proteins Hippo Signaling Pathway YAP-Signaling Proteins TEA Domain Transcription Factors
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Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways.

Cancer discovery Nov 18, 2020
Hippo pathway dysregulation occurs in multiple cancers through genetic and nongenetic alterations, resulting in translocation of YAP to the nucleus and activation of the TEAD family of transcription factors. Unlike other oncogenic pathways such as RA...
Humans Machine Learning Genomics Computational Biology Signal Transduction MAP Kinase Signaling System Cheminformatics Hippo Signaling Pathway
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