AIMC Topic: YAP-Signaling Proteins

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Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.

Cell genomics Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Animals Deep Learning Protein Binding Mice Signal Transduction Transcription Factors Protein Serine-Threonine Kinases Adaptor Proteins, Signal Transducing DNA-Binding Proteins Molecular Dynamics Simulation Phosphoproteins Trophoblasts Enhancer Elements, Genetic Muscle Proteins Hippo Signaling Pathway YAP-Signaling Proteins TEA Domain Transcription Factors
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Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model.

Lipids in health and disease Aug 24, 2024
BACKGROUND: Nonalcoholic Steatohepatitis (NASH) results from complex liver conditions involving metabolic, inflammatory, and fibrogenic processes. Despite its burden, there has been a lack of any approved food-and-drug administration therapy up till ...
Machine Learning Biomarkers Animals Male Rats Disease Models, Animal Liver MicroRNAs Non-alcoholic Fatty Liver Disease YAP-Signaling Proteins
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