Infertility affects millions of couples worldwide, and in vitro fertilization is a key therapeutic strategy for achieving parenthood. Despite advances, the first IVF attempt fails in ~60% of patients, highlighting the need for innovative solutions to...
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
In cattle, the physiological process of switching from cycling to pregnant is complex. Ultimately, that process relies on endometrial luminal epithelial cells and is based on the paracrine context of the uterine lumen. Cells either release luteolytic...
Journal of controlled release : official journal of the Controlled Release Society
Oct 28, 2024
There is a clinical need to develop lipid nanoparticles (LNPs) to deliver congenital therapies to the fetus during pregnancy. The aim of these therapies is to restore normal fetal development and prevent irreversible conditions after birth. As a firs...
Stem cell-based embryo models by cultured pluripotent and extra-embryonic lineage stem cells are novel platforms to model early postimplantation development. We showed that induced pluripotent stem cells (iPSCs) could form ITS (iPSCs and trophectoder...
Reproductive toxicology (Elmsford, N.Y.)
Nov 26, 2020
The use of models of stem cell differentiation to trophoblastic cells provides an effective perspective for understanding the early molecular events in the establishment and maintenance of human pregnancy. In combination with the newly developed deep...
OBJECTIVE:: To evaluate the association between the depth of trophoblastic infiltration and serum vascular endothelial growth factorconcentration in patients with an ampullary pregnancy.
International journal of biological macromolecules
Sep 1, 2025
Protein lactylation plays a critical regulatory role in various human diseases; however, its function in recurrent spontaneous abortion (RSA) remains unclear. In this study, we integrated scRNA-seq (GSE214607), bulk RNA-seq (GSE26787 and GSE165004) d...
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