AIMC Topic: Trophoblasts

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ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia.

Placenta Apr 18, 2025
INTRODUCTION: Preeclampsia (PE), a placenta-originated hypertensive disorder of pregnancy, lacks targeted therapies despite its significant contribution to maternal and fetal morbidity. Emerging evidence implicates autophagy dysregulation in PE patho...
Pre-Eclampsia Animals Trophoblasts Pregnancy Mice Female Intracellular Signaling Peptides and Proteins Apoptosis Adult Protein Serine-Threonine Kinases Placenta Humans Autophagy
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Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.

Cell genomics Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Protein Serine-Threonine Kinases Adaptor Proteins, Signal Transducing DNA-Binding Proteins Mice Signal Transduction Transcription Factors Enhancer Elements, Genetic Muscle Proteins Hippo Signaling Pathway Molecular Dynamics Simulation Phosphoproteins Trophoblasts Animals Deep Learning Protein Binding YAP-Signaling Proteins TEA Domain Transcription Factors
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Effectors and predictors of conceptus survival in cattle: What is next?

Domestic animal endocrinology Mar 7, 2025
In cattle, the physiological process of switching from cycling to pregnant is complex. Ultimately, that process relies on endometrial luminal epithelial cells and is based on the paracrine context of the uterine lumen. Cells either release luteolytic...
Artificial Intelligence Pregnancy Female Corpus Luteum Abortion, Veterinary Pregnancy, Animal Animals Trophoblasts Cattle Endometrium
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Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning.

Journal of controlled release : official journal of the Controlled Release Society Oct 28, 2024
There is a clinical need to develop lipid nanoparticles (LNPs) to deliver congenital therapies to the fetus during pregnancy. The aim of these therapies is to restore normal fetal development and prevent irreversible conditions after birth. As a firs...
Fetus Trophoblasts Gene Transfer Techniques Lipids Placenta Transfection Lung Nanoparticles Fibroblasts Humans Pregnancy Machine Learning Female Animals
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Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro.

Stem cell reports Apr 22, 2021
Stem cell-based embryo models by cultured pluripotent and extra-embryonic lineage stem cells are novel platforms to model early postimplantation development. We showed that induced pluripotent stem cells (iPSCs) could form ITS (iPSCs and trophectoder...
Transcriptome Mice Machine Learning Endoderm Embryo Implantation Embryo, Mammalian Trophoblasts Morphogenesis Bone Morphogenetic Protein 4 Cytokines Animals Gene Expression Regulation, Developmental Small Molecule Libraries Cell Polarity Induced Pluripotent Stem Cells Ectoderm
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Recognized trophoblast-like cells conversion from human embryonic stem cells by BMP4 based on convolutional neural network.

Reproductive toxicology (Elmsford, N.Y.) Nov 26, 2020
The use of models of stem cell differentiation to trophoblastic cells provides an effective perspective for understanding the early molecular events in the establishment and maintenance of human pregnancy. In combination with the newly developed deep...
Humans Cell Differentiation Neural Networks, Computer Gene Expression Regulation Trophoblasts Cells, Cultured Bone Morphogenetic Protein 4 Microscopy, Phase-Contrast Phenotype Human Embryonic Stem Cells
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Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy.

Clinics (Sao Paulo, Brazil) Dec 1, 2016
OBJECTIVE:: To evaluate the association between the depth of trophoblastic infiltration and serum vascular endothelial growth factorconcentration in patients with an ampullary pregnancy.
Pregnancy, Tubal Trophoblasts Gestational Age Cross-Sectional Studies Statistics, Nonparametric Adolescent Fallopian Tubes Female ROC Curve Child Humans Young Adult Prospective Studies Predictive Value of Tests Adult Pregnancy Vascular Endothelial Growth Factor A
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