AIMC Topic: Muscle Proteins

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Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.

Cell genomics Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Animals Deep Learning Protein Binding Mice Signal Transduction Transcription Factors Protein Serine-Threonine Kinases Adaptor Proteins, Signal Transducing DNA-Binding Proteins Molecular Dynamics Simulation Phosphoproteins Trophoblasts Enhancer Elements, Genetic Muscle Proteins Hippo Signaling Pathway YAP-Signaling Proteins TEA Domain Transcription Factors
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Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy.

Journal of the American Society for Mass Spectrometry Apr 8, 2020
Top-down mass spectrometry (MS) is a powerful tool for the identification and comprehensive characterization of proteoforms arising from alternative splicing, sequence variation, and post-translational modifications. However, the complex data set gen...
Humans Machine Learning Data Analysis Algorithms Sensitivity and Specificity Proteomics Protein Processing, Post-Translational Tandem Mass Spectrometry Alternative Splicing Sarcomeres Muscle Proteins
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