AIMC Topic: Hypromellose Derivatives

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A non-linear modelling approach to predict the dissolution profile of extended-release tablets.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Nov 28, 2024
This study proposes a novel non-linear modelling approach to predict the dissolution profiles of extended-release tablets, by combining a full-factorial design, curve fitting to the dissolution profiles, and artificial neural networks (ANN), with lin...
Nonlinear Dynamics Linear Models Drug Liberation Delayed-Action Preparations Excipients Chemistry, Pharmaceutical Hypromellose Derivatives Carboxymethylcellulose Sodium Least-Squares Analysis Solubility Tablets Neural Networks, Computer
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Convolutional neural network-based evaluation of chemical maps obtained by fast Raman imaging for prediction of tablet dissolution profiles.

International journal of pharmaceutics Apr 30, 2023
In this work, the capabilities of a state-of-the-art fast Raman imaging apparatus are exploited to gain information about the concentration and particle size of hydroxypropyl methylcellulose (HPMC) in sustained release tablets. The extracted informat...
Tablets Solubility Methylcellulose Neural Networks, Computer Delayed-Action Preparations Hypromellose Derivatives
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Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset.

International journal of pharmaceutics Jan 18, 2023
As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have emerged as power...
Technology, Pharmaceutical Hypromellose Derivatives Spectrum Analysis Neural Networks, Computer Tablets Retrospective Studies
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Effects of different high hydrostatic pressure-treated potato starch on the processing performance of dough-like model systems.

Food research international (Ottawa, Ont.) Nov 1, 2018
In this study, potato starch (PS) was processed by high hydrostatic pressure (HHP) at 200, 350 and 500 MPa for 30 min at 25 °C. Effects of HHP-treated PS on the processing performance of PS-gluten and PS-hydroxypropylmethylcellulose (HPMC) dough-like...
Glutens Hydrostatic Pressure Bread Fermentation Models, Chemical Hypromellose Derivatives Water Chemical Phenomena Starch Solanum tuberosum
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Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain.

Acta pharmaceutica (Zagreb, Croatia) Jun 1, 2016
A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (...
Cyclooxygenase Inhibitors Toothache Administration, Buccal Solubility Neural Networks, Computer Tablets Hexuronic Acids Technology, Pharmaceutical Humans Lidocaine Glucuronic Acid Drug Compounding Alginates Mouth Mucosa Adhesiveness Anesthetics, Local Hypromellose Derivatives Models, Chemical Flurbiprofen Kinetics
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