AIMC Topic: Immunoglobulin Class Switching

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Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.

PLoS computational biology May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
Neural Networks, Computer Interleukin-4 Immunoglobulin G Computer Simulation Animals Single-Cell Analysis RNA-Seq Mice Computational Biology Signal Transduction Mice, Inbred C57BL Gene Expression B-Lymphocytes Supervised Machine Learning Databases, Nucleic Acid Models, Immunological Receptors, Cytokine Recombination, Genetic Basic-Leucine Zipper Transcription Factors Immunoglobulin Class Switching NF-kappa B p50 Subunit STAT6 Transcription Factor
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