AIMC Topic: Interleukin-4

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A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.

PloS one Dec 31, 2024
The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have ...
Animals Image Processing, Computer-Assisted Mice Interleukin-4 Mice, Inbred C57BL Macrophages Cell Differentiation Cell Shape Support Vector Machine Cell Movement Lipopolysaccharides
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Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence.

Frontiers in immunology Jan 4, 2024
INTRODUCTION: The last decade has led to rapid developments and increased usage of computational tools at the single-cell level. However, our knowledge remains limited in how extracellular cues alter quantitative macrophage morphology and how such mo...
Granulocyte-Macrophage Colony-Stimulating Factor Humans Macrophages Tumor Necrosis Factor-alpha Interleukin-10 Cytokines Artificial Intelligence Interleukin-4 Macrophage Colony-Stimulating Factor Phenotype Cells, Cultured
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The spatial distribution of interleukin-4 (IL-4) reference values in China based on a back propagation (BP) neural network.

Geospatial health Sep 13, 2023
This study aimed to investigate the geospatial distribution of normal reference values of Interleukin 4 (IL-4) in healthy Chinese adults and to provide a basis for the development of standard references. IL-4 values of 5,221 healthy adults from 64 ci...
Neural Networks, Computer Humans Interleukin-4 Soil Adult China Reference Values
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Caffeoyl malic acid is a potential dual inhibitor targeting TNFα/IL-4 evaluated by a combination strategy of network analysis-deep learning-molecular simulation.

Computers in biology and medicine Mar 17, 2022
Atopic dermatitis (AD) is a common inflammatory skin disease involving multiple signaling pathways. One of the effective treatment strategies of AD is to develop a new drug capable of regulating the key therapeutic targets. Here we report the combina...
Humans Tumor Necrosis Factor-alpha Dermatitis, Atopic Malates Interleukin-4 Deep Learning
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Pseudocell Tracer-A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination.

PLoS computational biology May 3, 2021
Single cell RNA sequencing (scRNAseq) can be used to infer a temporal ordering of cellular states. Current methods for the inference of cellular trajectories rely on unbiased dimensionality reduction techniques. However, such biologically agnostic or...
Models, Immunological Receptors, Cytokine Recombination, Genetic Supervised Machine Learning Databases, Nucleic Acid STAT6 Transcription Factor Basic-Leucine Zipper Transcription Factors Immunoglobulin Class Switching NF-kappa B p50 Subunit Mice Computational Biology Signal Transduction Animals Mice, Inbred C57BL Immunoglobulin G Single-Cell Analysis Neural Networks, Computer Gene Expression Computer Simulation Interleukin-4 RNA-Seq B-Lymphocytes
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Effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on excisional wound healing in a rat's model.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Feb 1, 2019
OBJEVTIVE: To investigate the effects of extracts from Chuanwu (Aconitum Carmichaelii) and Banxia (Rhizoma Pinelliae) on the excisional wound healing in a rat's model.
Interleukin-4 Animals Fibroblast Growth Factor 2 Real-Time Polymerase Chain Reaction Wound Healing Interleukin-10 Transforming Growth Factor beta1 Pinellia Disease Models, Animal Tumor Necrosis Factor-alpha Rats Drugs, Chinese Herbal Aconitum Interleukin-2 Rats, Sprague-Dawley
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[Expression of Tim-3 on Peripheral CD56(+) NK Cells and ItsCorrelation with Liver Fibrosis in Patients withAdvanced Schistosomiasis].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases Oct 1, 2015
OBJECTIVE: To explore the expression of T cell immunoglobulin and mucin domain protein 3 (Tim-3) on CD56(+) NK cells in peripheral blood and its correlation with liver fibrosis indicators in patients with advanced schistosomiasis.
Interferon-gamma Hepatitis A Virus Cellular Receptor 2 Interleukin-4 Schistosomiasis Procollagen Collagen Type IV Humans Liver Cirrhosis Case-Control Studies Flow Cytometry Laminin Killer Cells, Natural Hyaluronic Acid Enzyme-Linked Immunosorbent Assay Membrane Proteins Peptide Fragments
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