AIMC Topic: Interleukin-1 Receptor-Associated Kinases

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Construction of IRAK4 inhibitor activity prediction model based on machine learning.

Molecular diversity Jul 6, 2024
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a crucial serine/threonine protein kinase that belongs to the IRAK family and plays a pivotal role in Toll-like receptor (TLR) and Interleukin-1 receptor (IL-1R) signaling pathways. Due to IRAK4's...
Humans Machine Learning Molecular Docking Simulation Protein Kinase Inhibitors Interleukin-1 Receptor-Associated Kinases
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Exploration and verification a 13-gene diagnostic framework for ulcerative colitis across multiple platforms via machine learning algorithms.

Scientific reports Jul 1, 2024
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with intricate pathogenesis and varied presentation. Accurate diagnostic tools are imperative to detect and manage UC. This study sought to construct a robust diagnostic model using gene...
Humans Machine Learning Algorithms Biomarkers Female Adult Male Gene Expression Profiling Transcriptome Case-Control Studies Colitis, Ulcerative Lipocalin-2 Interleukin-1 Receptor-Associated Kinases
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[MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2016
PURPOSE: To investigate the effects of miR-142-3p overexpression on secretion of inflammatory factors in human periodontal ligament cells (hPDLCs) induced by lipopolysaccharide (LPS) and its underlying mechanism.
Humans Tumor Necrosis Factor-alpha Interleukin-6 Inflammation Signal Transduction Lipopolysaccharides Cell Line MicroRNAs NF-kappa B Periodontal Ligament Transfection Interleukin-1 Receptor-Associated Kinases
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