Structural data provides important information on the proteins' function. Recent development of advanced machine learning and artificial intelligence tools, such as AlphaFold, have led to an explosion of predicted protein structures. However, many of...
Interactions between proteins and lipids are crucial for numerous cellular processes. Some of the lipid interacting segments in protein sequences are intrinsically disordered regions (IDRs), which may gain secondary structures upon binding. We collec...
BACKGROUND: Pesticides are crucial for protecting crops from pests and diseases to meet the growing global food demand. In the era of artificial intelligence (AI), computer-aided approaches have the potential to significantly enhance the efficiency a...
BACKGROUND: The internet is a primary source of health information for breast cancer patients, but online content quality varies widely. This study aimed to evaluate the capability of large language models (LLMs), including ChatGPT and Claude, to ass...
Journal of chemical information and modeling
Aug 11, 2025
Drug discovery is a lengthy and resource-intensive process that requires innovative computational techniques to expedite the transition from laboratory research to life-saving medications. Here, we introduce Qsarna, a comprehensive online platform th...
On the occasion of the 110th anniversary of the Chinese Medical Association, this article reflects on the author's over six decades of experience in medical education, including leadership roles as president and dean at multiple medical schools, shar...
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Aug 1, 2025
PURPOSE: This study compares ChatGPT-4o, equipped with its deep research feature, and DeepSeek R1, equipped with its deepthink feature-both enabling real-time online data access-in generating responses to frequently asked questions (FAQs) about anter...
Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions (IDRs) due to their lowered sequence conservation and unique sequence properties. Here, we present a web ...
Knowledge of protein-ligand binding sites (LBSs) is crucial for advancing our understanding of biology and developing practical applications in fields such as medicine or biotechnology. PrankWeb is a web server that allows users to predict LBSs from ...
Antisense oligonucleotides (ASOs) are a promising class of gene therapies that can modulate the gene expression. However, designing ASOs manually is resource-intensive and time-consuming. To address this, we introduce a user-friendly web server for A...
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