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NetGO: improving large-scale protein function prediction with massive network information.

Nucleic acids research Jul 2, 2019
Automated function prediction (AFP) of proteins is of great significance in biology. AFP can be regarded as a problem of the large-scale multi-label classification where a protein can be associated with multiple gene ontology terms as its labels. Bas...
Humans Sequence Homology, Amino Acid Sequence Analysis, Protein Prokaryotic Cells Gene Ontology Protein Interaction Mapping Sequence Alignment Amino Acid Sequence Structure-Activity Relationship Molecular Sequence Annotation Computational Biology Models, Molecular Proteins Internet Databases, Protein Machine Learning Software Animals Benchmarking Plants
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Doc2Hpo: a web application for efficient and accurate HPO concept curation.

Nucleic acids research Jul 2, 2019
We present Doc2Hpo, an interactive web application that enables interactive and efficient phenotype concept curation from clinical text with automated concept normalization using the Human Phenotype Ontology (HPO). Users can edit the HPO concepts aut...
Humans Software Data Curation Phenotype Internet User-Computer Interface Genes Biological Ontologies
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A systematic literature review of machine learning in online personal health data.

Journal of the American Medical Informatics Association : JAMIA Jun 1, 2019
OBJECTIVE: User-generated content (UGC) in online environments provides opportunities to learn an individual's health status outside of clinical settings. However, the nature of UGC brings challenges in both data collecting and processing. The purpos...
Internet Patient Portals Patient Generated Health Data Humans Machine Learning Social Media
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WHISTLE: a high-accuracy map of the human N6-methyladenosine (m6A) epitranscriptome predicted using a machine learning approach.

Nucleic acids research Apr 23, 2019
N 6-methyladenosine (m6A) is the most prevalent post-transcriptional modification in eukaryotes, and plays a pivotal role in various biological processes, such as splicing, RNA degradation and RNA-protein interaction. We report here a prediction fram...
Humans Protein Interaction Maps Sequence Analysis, RNA Machine Learning Transcriptome High-Throughput Nucleotide Sequencing Methylation Adenosine Epigenesis, Genetic Internet RNA
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Health promotion 4.0.

Health promotion international Apr 1, 2019
Artificial Intelligence Health Promotion Humans Social Media Internet Commerce
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Randomized controlled trial of an online machine learning-driven risk assessment and intervention platform for increasing the use of crisis services.

Journal of consulting and clinical psychology Apr 1, 2019
OBJECTIVE: Mental illness is a leading cause of disease burden; however, many barriers prevent people from seeking mental health services. Technological innovations may improve our ability to reach underserved populations by overcoming many existing ...
Mobile Applications Mental Health Services Internet Referral and Consultation Crisis Intervention Adult Male Risk Assessment Mental Disorders Female Young Adult Humans Machine Learning
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Integrating an Ontology of Radiology Differential Diagnosis with ICD-10-CM, RadLex, and SNOMED CT.

Journal of digital imaging Apr 1, 2019
An ontology offers a human-readable and machine-computable representation of the concepts in a domain and the relationships among them. Mappings between ontologies enable the reuse and interoperability of biomedical knowledge. We sought to map concep...
Biological Ontologies International Classification of Diseases Societies, Medical Diagnostic Imaging Internet Systematized Nomenclature of Medicine Humans Diagnosis, Differential
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Identifying concepts from medical images via transfer learning and image retrieval.

Mathematical biosciences and engineering : MBE Mar 8, 2019
Automatically identifying semantic concepts from medical images provides multimodal insights for clinical research. To study the effectiveness of concept detection on large scale medical images, we reconstructed over 230,000 medical image-concepts pa...
Semantics Humans Pattern Recognition, Automated Neural Networks, Computer Image Processing, Computer-Assisted Female Breast Neoplasms Area Under Curve Deep Learning Internet
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A new ensemble residual convolutional neural network for remaining useful life estimation.

Mathematical biosciences and engineering : MBE Jan 28, 2019
Remaining useful life (RUL) estimation is one of the most important component in prognostic health management (PHM) system in modern industry. It defined as the length from the current time to the end of the useful life. With the rapid development of...
Prognosis Time Factors Longevity Learning Internet Support Vector Machine Neural Networks, Computer Deep Learning Linear Models Algorithms Fuzzy Logic Computer Simulation
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Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources.

Nucleic acids research Jan 8, 2019
The Human Phenotype Ontology (HPO)-a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases-is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world. Its detaile...
Databases, Genetic Internet Whole Genome Sequencing Knowledge Bases Humans Rare Diseases Phenotype Genetic Variation Congenital Abnormalities Genetic Predisposition to Disease Biological Ontologies Computational Biology
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