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Kinetics

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The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning.

Nature communications
The study of biomolecular interactions between a drug and its biological target is of paramount importance for the design of novel bioactive compounds. In this paper, we report on the use of molecular dynamics (MD) simulations and machine learning to...

Comparison of ultrasonic with stirrer performance for removal of sunset yellow (SY) by activated carbon prepared from wood of orange tree: artificial neural network modeling.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
The present work focused on the removal of sunset yellow (SY) dye from aqueous solution by ultrasound-assisted adsorption and stirrer by activated carbon prepared from wood of an orange tree. Also, the artificial neural network (ANN) model was used f...

Artificial neural network (ANN) method for modeling of sunset yellow dye adsorption using zinc oxide nanorods loaded on activated carbon: Kinetic and isotherm study.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
In this research, ZnO nanoparticle loaded on activated carbon (ZnO-NPs-AC) was synthesized simply by a low cost and nontoxic procedure. The characterization and identification have been completed by different techniques such as SEM and XRD analysis. ...

DEKP: a deep learning model for enzyme kinetic parameter prediction based on pretrained models and graph neural networks.

Briefings in bioinformatics
The prediction of enzyme kinetic parameters is crucial for screening enzymes with high catalytic efficiency and desired characteristics to catalyze natural or non-natural reactions. Data-driven machine learning models have been explored to reduce exp...

MPEK: a multitask deep learning framework based on pretrained language models for enzymatic reaction kinetic parameters prediction.

Briefings in bioinformatics
Enzymatic reaction kinetics are central in analyzing enzymatic reaction mechanisms and target-enzyme optimization, and thus in biomanufacturing and other industries. The enzyme turnover number (kcat) and Michaelis constant (Km), key kinetic parameter...

Exploiting the structure of biochemical pathways to investigate dynamical properties with neural networks for graphs.

Bioinformatics (Oxford, England)
MOTIVATION: Dynamical properties of biochemical pathways (BPs) help in understanding the functioning of living cells. Their in silico assessment requires simulating a dynamical system with a large number of parameters such as kinetic constants and sp...

Exhaustive state-specific dissociation study of the N2(Σg+1)+N(S4) system using QCT combined with a neural network method.

The Journal of chemical physics
This work studies the exhaustive rovibrational state-specific collision-induced dissociation properties of the N2+N system by QCT (quasi-classical trajectory) combined with a neural network method based on the ab initio PES recently published by Varg...

Machine learning based prediction of phase ordering dynamics.

Chaos (Woodbury, N.Y.)
Machine learning has proven exceptionally competent in numerous applications of studying dynamical systems. In this article, we demonstrate the effectiveness of reservoir computing, a famous machine learning architecture, in learning a high-dimension...

Successes and challenges in using machine-learned activation energies in kinetic simulations.

The Journal of chemical physics
The prediction of the thermodynamic and kinetic properties of chemical reactions is increasingly being addressed by machine-learning (ML) methods, such as artificial neural networks (ANNs). While a number of recent studies have reported success in pr...

Physics-informed neural networks and functional interpolation for stiff chemical kinetics.

Chaos (Woodbury, N.Y.)
This work presents a recently developed approach based on physics-informed neural networks (PINNs) for the solution of initial value problems (IVPs), focusing on stiff chemical kinetic problems with governing equations of stiff ordinary differential ...