AIMC Topic: Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Discovery of a Novel and Potent LCK Inhibitor for Leukemia Treatment via Deep Learning and Molecular Docking.

Journal of chemical information and modeling Jun 7, 2024
The lymphocyte-specific protein tyrosine kinase (LCK) plays a crucial role in both T-cell development and activation. Dysregulation of LCK signaling has been demonstrated to drive the oncogenesis of T-cell acute lymphoblastic leukemia (T-ALL), thus p...
Humans Animals Molecular Docking Simulation Drug Discovery Antineoplastic Agents Deep Learning Cell Line, Tumor Mice Cell Proliferation Protein Kinase Inhibitors Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target.

Molecules (Basel, Switzerland) Nov 1, 2023
The lymphocyte-specific protein tyrosine kinase (LCK) is a critical target in leukemia treatment. However, potential off-target interactions involving LCK can lead to unintended consequences. This underscores the importance of accurately predicting t...
Machine Learning Molecular Docking Simulation Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Machine learning analysis of gene expression profile reveals a novel diagnostic signature for osteoporosis.

Journal of orthopaedic surgery and research Mar 15, 2021
BACKGROUND: Osteoporosis (OP) is increasingly prevalent with the aging of the world population. It is urgent to identify efficient diagnostic signatures for the clinical application.
Humans Machine Learning Osteoporosis Female Male Gene Expression Profiling Transcriptome Protein Interaction Maps RNA, Messenger Logistic Models Potassium Channels CD5 Antigens Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Signaling Lymphocytic Activation Molecule Family
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