PURPOSE: Total kidney volume (TKV) is an important measure in renal disease detection and monitoring. We developed a fully automated method to segment the kidneys from T -weighted MRI to calculate TKV of healthy control (HC) and chronic kidney diseas...
Forensic science international. Genetics
Mar 23, 2021
The prediction of human externally visible characteristics (EVCs) based solely on DNA information has become an established approach in forensic and anthropological genetics in recent years. While for a large set of EVCs, predictive models have alrea...
Journal of chemical information and modeling
Mar 23, 2021
Small molecules play a critical role in modulating biological systems. Knowledge of chemical-protein interactions helps address fundamental and practical questions in biology and medicine. However, with the rapid emergence of newly sequenced genes, t...
The increasing scope of genetic testing allowed by next-generation sequencing (NGS) dramatically increased the number of genetic variants to be interpreted as pathogenic or benign for adequate patient management. Still, the interpretation process oft...
Small cell lung cancer (SCLC) is a particularly aggressive tumor subtype, and dihydroorotate dehydrogenase (DHODH) has been demonstrated to be a therapeutic target for SCLC. Network pharmacology analysis and virtual screening were utilized to find ou...
Annals of the New York Academy of Sciences
Mar 22, 2021
The remarkable successes of convolutional neural networks (CNNs) in modern computer vision are by now well known, and they are increasingly being explored as computational models of the human visual system. In this paper, we ask whether CNNs might al...
Gradient Forests (GF) is a machine learning algorithm that is gaining in popularity for studying the environmental drivers of genomic variation and for incorporating genomic information into climate change impact assessments. Here we (i) provide the ...
Emotional distress is a common reason for seeking psychotherapy, and sharing emotional material is central to the process of psychotherapy. However, systematic research examining patterns of emotional exchange that occur during psychotherapy sessions...
Clinical chemistry and laboratory medicine
Mar 22, 2021
OBJECTIVES: Urine sample manipulation including substitution, dilution, and chemical adulteration is a continuing challenge for workplace drug testing, abstinence control, and doping control laboratories. The simultaneous detection of sample manipula...
Neural networks : the official journal of the International Neural Network Society
Mar 22, 2021
Multi-agent deep reinforcement learning (MDRL) has been widely applied in multi-intersection traffic signal control. The MDRL algorithms produce the decentralized cooperative traffic-signal policies via specialized multi-agent settings in certain tra...
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