AI Medical Compendium Topic

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Models, Neurological

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Strategies for feature extraction from structural brain imaging in lesion-deficit modelling.

Human brain mapping
High-dimensional modelling of post-stroke deficits from structural brain imaging is highly relevant to basic cognitive neuroscience and bears the potential to be translationally used to guide individual rehabilitation measures. One strategy to optimi...

Constrained plasticity reserve as a natural way to control frequency and weights in spiking neural networks.

Neural networks : the official journal of the International Neural Network Society
Biological neurons have adaptive nature and perform complex computations involving the filtering of redundant information. However, most common neural cell models, including biologically plausible, such as Hodgkin-Huxley or Izhikevich, do not possess...

Predicting pediatric anxiety from the temporal pole using neural responses to emotional faces.

Scientific reports
A prominent cognitive aspect of anxiety is dysregulation of emotional interpretation of facial expressions, associated with neural activity from the amygdala and prefrontal cortex. We report machine learning analysis of fMRI results supporting a key ...

Automatic detection of pathological myopia using machine learning.

Scientific reports
Pathological myopia is a severe case of myopia, i.e., nearsightedness. Pathological myopia is also known as degenerative myopia because it ultimately leads to blindness. In pathological myopia, certain myopia-specific pathologies occur at the eye's p...

A strategy for mapping biophysical to abstract neuronal network models applied to primary visual cortex.

PLoS computational biology
A fundamental challenge for the theoretical study of neuronal networks is to make the link between complex biophysical models based directly on experimental data, to progressively simpler mathematical models that allow the derivation of general opera...

Unveiling functions of the visual cortex using task-specific deep neural networks.

PLoS computational biology
The human visual cortex enables visual perception through a cascade of hierarchical computations in cortical regions with distinct functionalities. Here, we introduce an AI-driven approach to discover the functional mapping of the visual cortex. We r...

Structured patterns of activity in pulse-coupled oscillator networks with varied connectivity.

PloS one
Identifying coordinated activity within complex systems is essential to linking their structure and function. We study collective activity in networks of pulse-coupled oscillators that have variable network connectivity and integrate-and-fire dynamic...

Single cortical neurons as deep artificial neural networks.

Neuron
Utilizing recent advances in machine learning, we introduce a systematic approach to characterize neurons' input/output (I/O) mapping complexity. Deep neural networks (DNNs) were trained to faithfully replicate the I/O function of various biophysical...

Dendritic normalisation improves learning in sparsely connected artificial neural networks.

PLoS computational biology
Artificial neural networks, taking inspiration from biological neurons, have become an invaluable tool for machine learning applications. Recent studies have developed techniques to effectively tune the connectivity of sparsely-connected artificial n...

Parallel and Recurrent Cascade Models as a Unifying Force for Understanding Subcellular Computation.

Neuroscience
Neurons are very complicated computational devices, incorporating numerous non-linear processes, particularly in their dendrites. Biophysical models capture these processes directly by explicitly modelling physiological variables, such as ion channel...