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Myeloid Cell Leukemia Sequence 1 Protein

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Adenosine Triphosphate Protects from Elevated Extracellular Calcium-Induced Damage in Human Proximal Kidney Cells: Using Deep Learning to Predict Cytotoxicity.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 36126285
BACKGROUND/AIMS: In kidney, extracellular [Ca] can modulate intracellular [Ca] to control key cellular processes. Hence, extracellular [Ca] is normally maintained within narrow range. We tested effect of extracellular ATP on viability of human proxim...
Adenosine Triphosphate Artificial Intelligence Calcium Calcium Chloride Calmodulin Deep Learning Humans Kidney Myeloid Cell Leukemia Sequence 1 Protein RNA, Messenger
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Machine Learning Deciphered Molecular Mechanistics with Accurate Kinetic and Thermodynamic Prediction.

Journal of chemical theory and computation 38394691
Time-lagged independent component analysis (tICA) and the Markov state model (MSM) have been extensively employed for extracting conformational dynamics and kinetic community networks from unbiased trajectory ensembles. However, these techniques may ...
Humans Kinetics Machine Learning Markov Chains Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Thermodynamics
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Application of molecular dynamics-based pharmacophore and machine learning approaches to identify novel Mcl1 inhibitors through drug repurposing and mechanics research.

Physical chemistry chemical physics : PCCP 38780456
Myeloid cell leukemia 1 (Mcl1), a critical protein that regulates apoptosis, has been considered as a promising target for antitumor drugs. The conventional pharmacophore screening approach has limitations in conformation sampling and data mining. He...
Antineoplastic Agents Cell Line, Tumor Drug Repositioning Fluvastatin Humans Machine Learning Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Pharmacophore Quantum Theory
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