AIMC Topic: N-Acetylglucosaminyltransferases

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Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.

Acta pharmacologica Sinica Feb 21, 2025
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...
Humans Animals Antineoplastic Agents Cell Line, Tumor Mice Autophagy Lysosomes Thiazoles Multiple Myeloma Pyrans Cell Cycle Proteins N-Acetylglucosaminyltransferases Bortezomib
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O-GlcNAcPRED-DL: Prediction of Protein O-GlcNAcylation Sites Based on an Ensemble Model of Deep Learning.

Journal of proteome research Dec 6, 2023
O-linked β--acetylglucosamine (O-GlcNAc) is a post-translational modification (i.e., O-GlcNAcylation) on serine/threonine residues of proteins, regulating a plethora of physiological and pathological events. As a dynamic process, O-GlcNAc functions i...
Humans Animals Deep Learning Mice Protein Processing, Post-Translational Acetylglucosamine Proteins N-Acetylglucosaminyltransferases
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A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs.

BMC bioinformatics Dec 9, 2015
Protein O-GlcNAcylation, involving the β-attachment of single N-acetylglucosamine (GlcNAc) to the hydroxyl group of serine or threonine residues, is an O-linked glycosylation catalyzed by O-GlcNAc transferase (OGT). Molecular level investigation of t...
Machine Learning Algorithms Peptides User-Computer Interface Glycosylation Support Vector Machine Mass Spectrometry Acetylglucosamine Proteins Internet Substrate Specificity Amino Acid Motifs N-Acetylglucosaminyltransferases
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