AIMC Topic: Lysosomes
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An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Nature communications
Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Acta pharmacologica Sinica
Feb 21, 2025
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by abnormal proliferation of cloned plasma cells. Given the aggressive nature and drug resistance of MM cells, identification of novel genes could provide valuable insights for...
UNET-FLIM: A Deep Learning-Based Lifetime Determination Method Facilitating Real-Time Monitoring of Rapid Lysosomal pH Variations in Living Cells.
Analytical chemistry
Feb 4, 2025
Lifetime determination plays a crucial role in fluorescence lifetime imaging microscopy (FLIM). We introduce UNET-FLIM, a deep learning architecture based on a one-dimensional U-net, specifically designed for lifetime determination. UNET-FLIM focuses...
Integrating mitochondrial and lysosomal gene analysis for breast cancer prognosis using machine learning.
Scientific reports
Jan 27, 2025
The impact of mitochondrial and lysosomal co-dysfunction on breast cancer patient outcomes is unclear. The objective of this study is to develop a predictive machine learning (ML) model utilizing mitochondrial and lysosomal co-regulators in order to ...
TFEB/LAMP2 contributes to PM-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.
Journal of environmental sciences (China)
Oct 5, 2023
Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathol...
Facial features of lysosomal storage disorders.
Expert review of endocrinology & metabolism
Nov 16, 2022
INTRODUCTION: The use of facial recognition technology has diversified the diagnostic toolbelt for clinicians and researchers for the accurate diagnoses of patients with rare and challenging disorders. Specific identifiers in patient images can be gr...
An in vitro assay and artificial intelligence approach to determine rate constants of nanomaterial-cell interactions.
Scientific reports
Sep 26, 2019
In vitro assays and simulation technologies are powerful methodologies that can inform scientists of nanomaterial (NM) distribution and fate in humans or pre-clinical species. For small molecules, less animal data is often needed because there are a ...
DeepPhagy: a deep learning framework for quantitatively measuring autophagy activity in .
Autophagy
Jun 20, 2019
Seeing is believing. The direct observation of GFP-Atg8 vacuolar delivery under confocal microscopy is one of the most useful end-point measurements for monitoring yeast macroautophagy/autophagy. However, manually labelling individual cells from larg...
An Intelligent DNA Nanorobot with Enhanced Protein Lysosomal Degradation of HER2.
Nano letters
Jun 5, 2019
DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have been considered one of the most promising nanocarriers. In the present study, we...
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Archives of toxicology
Sep 22, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanis...
Liver
Chemical and Drug Induced Liver Injury
Molecular Structure
Humans
Severity of Illness Index
Expert Systems
Hepatobiliary Elimination
Artificial Intelligence
Oxidative Stress
Drugs, Investigational
Evidence-Based Medicine
Animals
Computational Biology
Mitochondria, Liver
Lysosomes
Adaptive Immunity
Models, Biological
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