Journal of agricultural and food chemistry
Aug 6, 2025
Dipeptidyl peptidase-IV (DPP-IV) inhibitors play a critical role in the treatment of diabetes and metabolic diseases. This study combines computational simulations with experimental validation to identify peptides with potential DPP-IV inhibitory act...
Protein science : a publication of the Protein Society
Aug 1, 2025
Within the central nervous system, the myelin sheath is composed of elements known as myelin autoantigens that are mistakenly targeted by the immune system in multiple sclerosis (MS). This autoimmune attack leads to the destruction of myelin, resulti...
Protein science : a publication of the Protein Society
Aug 1, 2025
The accurate prediction of neurotoxicity in peptides and proteins is essential for the safety evaluation of therapeutic proteins and genetically modified (GM) organisms. Existing tools, including our earlier method NTxPred, typically use a single pre...
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: T cells play a vital role in the immune system by recognizing and eliminating infected or cancerous cells, thus driving adaptive immune responses. Their activation is triggered by the binding of T cell receptors (TCRs) to ep...
Globally, cancer remains a major health challenge due to its high mortality rates. Traditional experimental approaches and therapies are resource-intensive and often cause significant side effects. Anticancer peptides (ACPs) have emerged as alternati...
This review explores the health benefits of bioactive peptides (BAPs) from fermented milk proteins, emphasizing the transformative role of artificial intelligence (AI) and machine learning (ML) in advancing this field. BAPs exhibit diverse biological...
Viruses are transmitted through multiple routes and can cause a wide range of diseases. Antiviral peptides (AVPs) have emerged as a cost-effective and low-side-effect strategy for combating viral infections. However, identifying antiviral peptides ex...
Many members of the broad family of enzymes, known as YcaOs have been shown to install azoline heterocycles post-translationally into peptide substrates. These moieties can help rigidify structures and contribute to the potent bioactivities of the ev...
Biochemical and biophysical research communications
Jun 20, 2025
The MYC protein is an oncoprotein that plays a crucial role in various cancers. Although its significance has been well recognized in research, the development of drugs targeting MYC remains relatively slow. In this study, we developed a novel MYC pe...
Peptide toxicity prediction holds significant importance in drug development and biotechnology, as accurately identifying toxic peptide sequences is crucial for designing safer peptide-based drugs. This study proposes a deep learning-based model for ...
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