Analytical methods : advancing methods and applications
Dec 11, 2020
Owing to the growing interest in the application of Raman spectroscopy for quantitative purposes in solid pharmaceutical preparations, an article on the identification of compositions in excipient dominated drugs based on Raman spectra is presented. ...
Predicting compounds with single- and multi-target activity and exploring origins of compound specificity and promiscuity is of high interest for chemical biology and drug discovery. We present a large-scale analysis of compound promiscuity including...
A new artificial intelligence-based predictive modeling framework called DrugCell could accurately predict effective drugs and treatment combinations based on tumor genotype, according to a proof-of-concept analysis.
High concentration monoclonal antibody drug products represent a special segment of biopharmaceuticals. In contrast to other monoclonal antibody products, high concentration monoclonal antibodies are injected subcutaneously helping increase patient c...
Journal of pharmaceutical and biomedical analysis
Nov 20, 2020
The limitation and control of genotoxic impurities (GTIs) has continued to receive attention from pharmaceutical companies and authorities for several decades. Because GTIs have the ability to damage deoxyribonucleic acid (DNA) and the potential to c...
Journal of chemical information and modeling
Nov 3, 2020
Semi-supervised learning has proved its efficacy in utilizing extensive unlabeled data to alleviate the use of a large amount of supervised data and improve model performance. Despite its tremendous potential, semi-supervised learning has yet to be i...
Rapidly developing single-cell sequencing analyses produce more comprehensive profiles of the genomic, transcriptomic, and epigenomic heterogeneity of tumor subpopulations than do traditional bulk sequencing analyses. Moreover, single-cell techniques...
Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in CYP2D6 are responsible for interindividual heterogeneity in drug response that can lead to drug ...
Deep neural networks often achieve high predictive accuracy on biological problems, but it can be hard to contextualize how and explain why predictions are made. In this issue, Kuenzi et al. model the sensitivity of cancers to drugs using deep neural...
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