AIMC Topic: Piperazines

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Durability of dolutegravir plus boosted darunavir as salvage or simplification of salvage regimens in HIV-1 infected, highly treatment-experienced subjects.

HIV clinical trials Dec 1, 2018
BACKGROUND: Dolutegravir (DTG) plus boosted darunavir (bDRV) is a compact, adherence-friendly salvage regimen with the highest genetic barrier to HIV-1 resistance.
Humans Female Reproducibility of Results Aged Adult Male Middle Aged HIV Infections Cohort Studies Pyridones Oxazines Heterocyclic Compounds, 3-Ring Piperazines Italy HIV-1 Darunavir HIV Protease Inhibitors HIV Integrase Inhibitors Salvage Therapy
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PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient.

JCO clinical cancer informatics Dec 1, 2018
PURPOSE: The majority of patients with cancer receive treatments that are minimally informed by omics data. We propose a precision medicine computational framework, PANOPLY (Precision Cancer Genomic Report: Single Sample Inventory), to identify and p...
Humans Machine Learning Precision Medicine Female Antineoplastic Agents Genomics Triple Negative Breast Neoplasms Neoadjuvant Therapy Piperazines Drug Resistance, Neoplasm Phthalazines
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