AIMC Topic: Polymyxin B

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Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Feb 12, 2020
OBJECTIVES: Increased rates of carbapenem-resistant strains of Acinetobacter baumannii have forced clinicians to rely upon last-line agents, such as the polymyxins, or empirical, unoptimized combination therapy. Therefore, the objectives of this stud...
Humans Machine Learning Anti-Bacterial Agents Drug Resistance, Bacterial Microbial Sensitivity Tests Drug Therapy, Combination Meropenem Acinetobacter Infections Acinetobacter baumannii Carbapenems Polymyxin B
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A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles.

Journal of biomedical nanotechnology Apr 1, 2017
This in vitro study aimed to investigate the synergistic antibacterial activity of polymyxin B in combination with 2 nm silver nanoparticles (NPs) against Gram-negative pathogens commonly isolated from the cystic fibrosis (CF) lung. The in vitro syne...
Humans Anti-Infective Agents Treatment Outcome Drug Combinations Dose-Response Relationship, Drug Cell Survival Metal Nanoparticles Silver Diffusion Cystic Fibrosis Drug Synergism Bacterial Physiological Phenomena Administration, Inhalation Pneumonia, Bacterial Polymyxin B Respiratory Therapy
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Validation of an UV spectrophotometric assay for the quantification of polymyxin B in solid lipid nanoparticles.

Die Pharmazie Nov 1, 2015
Polymyxins are efficient antibiotic drugs used for the treatment of Gram-negative bacterial infections. These compounds are not absorbed in the gastrointestinal tract and are responsible for serious toxicological effects. In order to enhance their th...
Algorithms Anti-Bacterial Agents Reproducibility of Results Nanoparticles Lipids Drug Compounding Delayed-Action Preparations Spectrophotometry, Ultraviolet Polymyxin B
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