AIMC Topic: Receptors, Androgen

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Machine Learning Consensus To Predict the Binding to the Androgen Receptor within the CoMPARA Project.

Journal of chemical information and modeling Feb 11, 2019
The nuclear androgen receptor (AR) is one of the most relevant biological targets of Endocrine Disrupting Chemicals (EDCs), which produce adverse effects by interfering with hormonal regulation and endocrine system functioning. This paper describes n...
Androgens Androgen Receptor Antagonists Molecular Docking Simulation Drug Discovery Receptors, Androgen Endocrine Disruptors Protein Binding Humans Machine Learning Software
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Efficient prediction of progesterone receptor interactome using a support vector machine model.

International journal of molecular sciences Mar 3, 2015
Protein-protein interaction (PPI) is essential for almost all cellular processes and identification of PPI is a crucial task for biomedical researchers. So far, most computational studies of PPI are intended for pair-wise prediction. Theoretically, p...
Area Under Curve Humans Receptors, Androgen Receptors, Progesterone Protein Interaction Domains and Motifs Receptors, Estrogen Support Vector Machine Cluster Analysis ROC Curve Proteome
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Small Molecules Targeting the Structural Dynamics of AR-V7 Partially Disordered Proteins Using Deep Ensemble Docking.

Journal of chemical theory and computation May 13, 2025
The extensive conformational dynamics of partially disordered proteins hinders the efficiency of traditional in-silico structure-based drug discovery approaches due to the challenge of screening large chemical spaces of compounds, albeit with an exce...
Humans Protein Conformation Molecular Docking Simulation Binding Sites Molecular Dynamics Simulation Small Molecule Libraries Intrinsically Disordered Proteins Receptors, Androgen
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D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology.

Reproduction, fertility, and development Jun 1, 2018
Male broiler breeders (n=32) of 55 weeks of age were administered four different doses of capsulated d-aspartate (DA; 0, 100, 200 or 300mgkg-1day-1, p.o. (DA0, DA100, DA200 and DA300 respectively)) for 12 successive weeks to assess reproductive perfo...
Proliferating Cell Nuclear Antigen Gene Expression Semen Analysis Receptors, Androgen Spermatogenesis Receptors, N-Methyl-D-Aspartate D-Aspartic Acid Cholesterol Side-Chain Cleavage Enzyme Drosophila Proteins Reproduction Chickens Testis Animals Male
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A big data approach with artificial neural network and molecular similarity for chemical data mining and endocrine disruption prediction.

Indian journal of pharmacology Jan 1, 2018
CONTEXT: Chemical toxicity prediction at early stage drug discovery phase has been researched for years, and newest methods are always investigated. Research data comprising chemical physicochemical properties, toxicity, assay, and activity details c...
Machine Learning Animals Drug Discovery Humans Neural Networks, Computer Data Mining Inhibitory Concentration 50 Receptors, Androgen Big Data Models, Theoretical Endocrine Disruptors Receptors, Estrogen
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The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation.

European cytokine network Nov 1, 2016
BACKGROUND: The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the absence of androgens to induce prostate cancer progression. The purpose of this study was to investigate whether the co-activator steroid receptor coactivator-1 (...
Nuclear Receptor Co-Repressor 2 Nuclear Receptor Coactivator 1 Prostatic Neoplasms Receptors, Androgen Male Cell Line, Tumor Humans Neoplasm Proteins Interleukin-6
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Male Cell Line, Tumor Gene Expression Regulation, Neoplastic Gene Expression RNA, Messenger Humans Oligonucleotide Array Sequence Analysis Repressor Proteins Dihydrotestosterone Fibronectins Androgens Down-Regulation Blotting, Western Receptors, Androgen Prostatic Neoplasms
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