AIMC Topic: Single Molecule Imaging
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In-Cell Single-Molecule Analysis of Molecular State and Reaction Kinetics Coupling.
Advances in experimental medicine and biology
Jan 1, 2021
Cellular signaling is regulated by the spatiotemporal dynamics and kinetics of molecular behavior. To investigate the mechanisms at the molecular level, fluorescence single-molecule analysis is an effective method owing to the direct observation of i...
Classification of particle trajectories in living cells: Machine learning versus statistical testing hypothesis for fractional anomalous diffusion.
Physical review. E
Sep 1, 2020
Single-particle tracking (SPT) has become a popular tool to study the intracellular transport of molecules in living cells. Inferring the character of their dynamics is important, because it determines the organization and functions of the cells. For...
Large-scale single-molecule imaging aided by artificial intelligence.
Microscopy (Oxford, England)
Apr 8, 2020
Single-molecule imaging analysis has been applied to study the dynamics and kinetics of molecular behaviors and interactions in living cells. In spite of its high potential as a technique to investigate the molecular mechanisms of cellular phenomena,...
Deep-learning with synthetic data enables automated picking of cryo-EM particle images of biological macromolecules.
Bioinformatics (Oxford, England)
Feb 15, 2020
MOTIVATION: Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique for determining 3D structures of biological macromolecules at near-atomic resolution. However, this approach requires picking huge numbers of macromolecula...
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