Antimicrobial resistance (AMR) is a global health concern that complicates the effective treatment of infections, resulting in an increased severity of illness and elevated healthcare costs. Traditional phenotypic antimicrobial susceptibility testing...
Single-cell analysis is essential for uncovering heterogeneous biological functions that arise from intricate cellular responses. Here, microfluidic droplet arrays enable high-throughput data collection through cell encapsulation in picoliter volumes...
For effective treatment of bacterial infections, it is essential to identify the species causing the infection as early as possible. Current methods typically require hours of overnight culturing of a bacterial sample and a larger quantity of cells t...
BACKGROUND: In assisted reproductive technology, evaluating the quality of the embryo is crucial when selecting the most viable embryo for transferring to a woman. Assessment also plays an important role in determining the optimal transfer time, eith...
Systems biology in reproductive medicine
Aug 26, 2025
Early embryo development and competence mechanisms are paramount to ART's success but are still underexplored in human-relevant animal models. Clinical embryo evaluation remains largely based on subjectively evaluated morphological characteristics. I...
Oscillations are a common phenomenon in cell biology. They are based on non-linear coupling of biochemical reactions and can show rich dynamic behavior as found in, for example, glycolysis of yeast cells. Here, we show that dynamic mode decomposition...
Accurate embryo assessment on embryonic day 3 of assisted reproductive technology (ART) is crucial for deciding whether to continue the culture until day 5 (blastocyst stage) or opt for earlier transfer or cryopreservation. Prolonged culture often im...
Computer methods and programs in biomedicine
Jun 4, 2025
BACKGROUND AND OBJECTIVE: Predicting cardiovascular risk is critical for the therapy and control of cardiovascular illnesses. This work studies screening the toxicity of three drugs, (E-4031, isoprenaline, and sertindole) with various concentrations ...
We previously developed the CellPhe toolkit, an open-source R package for automated cell phenotyping from ptychography time-lapse videos. To align with the growing adoption of python-based image analysis tools and to enhance interoperability with wid...
Monitoring and tracking of cell motion is a key component for understanding disease mechanisms and evaluating the effects of treatments. Time-lapse optical microscopy has been commonly employed for studying cell cycle phases. However, usual manual ce...
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