AIMC Topic: Pharmacology

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Enhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI-Based Mixed Methods Study.

JMIR medical education
BACKGROUND: Medical students often struggle to engage with and retain complex pharmacology topics during their preclinical education. Traditional teaching methods can lead to passive learning and poor long-term retention of critical concepts.

Mechanism-based organization of neural networks to emulate systems biology and pharmacology models.

Scientific reports
Deep learning neural networks are often described as black boxes, as it is difficult to trace model outputs back to model inputs due to a lack of clarity over the internal mechanisms. This is even true for those neural networks designed to emulate me...

Artificial intelligence and the future of life sciences.

Drug discovery today
Over the past few decades, the number of health and 'omics-related data' generated and stored has grown exponentially. Patient information can be collected in real time and explored using various artificial intelligence (AI) tools in clinical trials;...

Pharm-AutoML: An open-source, end-to-end automated machine learning package for clinical outcome prediction.

CPT: pharmacometrics & systems pharmacology
Although there is increased interest in utilizing machine learning (ML) to support drug development, technical hurdles associated with complex algorithms have limited widespread adoption. In response, we have developed Pharm-AutoML, an open-source Py...

Utilizing Artificial Intelligence to Manage COVID-19 Scientific Evidence Torrent with Risklick AI: A Critical Tool for Pharmacology and Therapy Development.

Pharmacology
INTRODUCTION: The SARS-CoV-2 pandemic has led to one of the most critical and boundless waves of publications in the history of modern science. The necessity to find and pursue relevant information and quantify its quality is broadly acknowledged. Mo...

Reduction of quantitative systems pharmacology models using artificial neural networks.

Journal of pharmacokinetics and pharmacodynamics
Quantitative systems pharmacology models are often highly complex and not amenable to further simulation and/or estimation analyses. Model-order reduction can be used to derive a mechanistically sound yet simpler model of the desired input-output rel...

Prediction of pharmacological activities from chemical structures with graph convolutional neural networks.

Scientific reports
Many therapeutic drugs are compounds that can be represented by simple chemical structures, which contain important determinants of affinity at the site of action. Recently, graph convolutional neural network (GCN) models have exhibited excellent res...

Modeling drug mechanism of action with large scale gene-expression profiles using GPAR, an artificial intelligence platform.

BMC bioinformatics
BACKGROUND: Querying drug-induced gene expression profiles with machine learning method is an effective way for revealing drug mechanism of actions (MOAs), which is strongly supported by the growth of large scale and high-throughput gene expression d...

Single-Cell Techniques and Deep Learning in Predicting Drug Response.

Trends in pharmacological sciences
Rapidly developing single-cell sequencing analyses produce more comprehensive profiles of the genomic, transcriptomic, and epigenomic heterogeneity of tumor subpopulations than do traditional bulk sequencing analyses. Moreover, single-cell techniques...

Advancing Drug Discovery via Artificial Intelligence.

Trends in pharmacological sciences
Drug discovery and development are among the most important translational science activities that contribute to human health and wellbeing. However, the development of a new drug is a very complex, expensive, and long process which typically costs 2....