AIMC Topic: Sterol Esterase

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A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.

Nature communications Jun 7, 2021
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compound...
Humans Animals Transcriptome Deep Learning Mice Computational Biology Mutation Phenethylamines HEK293 Cells tau Proteins Sterol Esterase Pyridazines Mice, Transgenic Cystic Fibrosis Transmembrane Conductance Regulator RNA Splicing Exons MutL Protein Homolog 1 Gene Targeting
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Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry.

Journal of pharmaceutical and biomedical analysis Dec 21, 2017
The potential use of cholesterol esterases was tested to avoid alkaline hydrolysis for cleavage of plasma esterified oxysterols. The enzymatic hydrolysis was optimized by testing two sources of enzyme-Pseudomonas and bovine pancreas, presence of surf...
Humans Reproducibility of Results Animals Male Chromatography, Liquid Bacterial Proteins Tandem Mass Spectrometry Pseudomonas aeruginosa Solid Phase Extraction Hydrolysis Animals, Genetically Modified Calibration Reference Standards Cytochrome P450 Family 7 Oxysterols Rats, Inbred F344 Steroid Hydroxylases Sterol Esterase
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