AIMC Topic: Transcription Initiation, Genetic

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ReFeaFi: Genome-wide prediction of regulatory elements driving transcription initiation.

PLoS computational biology Sep 7, 2021
Regulatory elements control gene expression through transcription initiation (promoters) and by enhancing transcription at distant regions (enhancers). Accurate identification of regulatory elements is fundamental for annotating genomes and understan...
Humans Deep Learning Genome-Wide Association Study Computational Biology Models, Genetic Mutation Gene Expression Regulation Genome, Human Promoter Regions, Genetic Molecular Sequence Annotation Enhancer Elements, Genetic Genes, Reporter Regulatory Sequences, Nucleic Acid Transcription Initiation, Genetic
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Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.

Nature communications Jun 2, 2021
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene ...
Humans Neural Networks, Computer Animals Deep Learning Mice Computational Biology A549 Cells Neurodegenerative Diseases High-Throughput Nucleotide Sequencing Base Sequence Genome, Human Polymorphism, Genetic Promoter Regions, Genetic Enhancer Elements, Genetic Microsatellite Repeats Transcription Initiation Site Transcription Initiation, Genetic
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