AIMC Topic: TRPA1 Cation Channel

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Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects.

European journal of pain (London, England) Jan 16, 2018
BACKGROUND: Pain in response to noxious cold has a complex molecular background probably involving several types of sensors. A recent observation has been the multimodal distribution of human cold pain thresholds. This study aimed at analysing reprod...
Humans Machine Learning Female Reproducibility of Results Young Adult Adult Male Middle Aged Adolescent Pain Healthy Volunteers Cold Temperature Pain Threshold Pain Perception TRPA1 Cation Channel
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Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Pain Jul 1, 2018
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. Howeve...
Humans Machine Learning TRPV Cation Channels Genotype Genetic Association Studies Pain High-Throughput Nucleotide Sequencing Hot Temperature Pain Threshold Capsaicin TRPA1 Cation Channel
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