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TRPA1 Cation Channel

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Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects.

European journal of pain (London, England) 29336514
BACKGROUND: Pain in response to noxious cold has a complex molecular background probably involving several types of sensors. A recent observation has been the multimodal distribution of human cold pain thresholds. This study aimed at analysing reprod...
Adolescent Adult Cold Temperature Female Healthy Volunteers Humans Machine Learning Male Middle Aged Pain Pain Perception Pain Threshold Reproducibility of Results TRPA1 Cation Channel Young Adult
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Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.

Pain 29596157
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. Howeve...
Capsaicin Genetic Association Studies Genotype High-Throughput Nucleotide Sequencing Hot Temperature Humans Machine Learning Pain Pain Threshold TRPA1 Cation Channel TRPV Cation Channels
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