AIMC Topic: Viral Nonstructural Proteins

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On the Origins of Hepatitis C Virus NS5B Polymerase Inhibitory Activity Using Machine Learning Approaches.

Current topics in medicinal chemistry Jan 1, 2015
Inhibition of non-structural protein 5B (NS5B) represents an attractive strategy for the therapeutic treatment of hepatitis C virus (HCV). In this study, machine learning classifiers such as artificial neural network (ANN), support vector machine (SV...
Machine Learning Drug Design Structure-Activity Relationship Molecular Structure High-Throughput Screening Assays Enzyme Inhibitors Viral Nonstructural Proteins
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Classification models of HCV NS3 protease inhibitors based on support vector machine (SVM).

Combinatorial chemistry & high throughput screening Jan 1, 2015
Inhibition of the hepatitis C virus (HCV) non-structural protein 3 (NS3) serine protease by molecule inhibitors is an attractive strategy for the treatment of hepatitis C. We built four classification models based on a dataset of 413 HCV NS3 protease...
Humans Molecular Docking Simulation Support Vector Machine Hepacivirus Hepatitis C Quantitative Structure-Activity Relationship Viral Nonstructural Proteins Protease Inhibitors Databases, Pharmaceutical
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