AIMC Topic: Viral Nonstructural Proteins

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Prokaryotic Expression of Hepatitis C Virus-NS3 Protein and Preparation of a Monoclonal Antibody.

Monoclonal antibodies in immunodiagnosis and immunotherapy Dec 1, 2017
Hepatitis C virus (HCV) is a significant health threat that has been extensively investigated worldwide. Improving the sensitivity and specificity of laboratory tests for screening and early diagnosis of HCV in a relevant population is an effective m...
Humans Aged Young Adult Adult Animals Middle Aged Adolescent Recombinant Proteins Enzyme-Linked Immunosorbent Assay Mice, Inbred BALB C Antibodies, Monoclonal Hepatitis C Viral Nonstructural Proteins Cross Reactions Hepatitis C Antibodies
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Model Selection for PCA-Linear SVM for automated detection of NS1 molecule from Raman spectra of salivary mixture.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Aug 1, 2015
Of recent, detection of Non-structural Protein 1 (NS1) in saliva has become appealing, as it may lead to a noninvasive detection method for NS1-related diseases at the febrile phase, before complication developed. NS1 is found to have a molecular fin...
Spectrum Analysis, Raman Support Vector Machine Saliva Linear Models Viral Nonstructural Proteins
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On the Origins of Hepatitis C Virus NS5B Polymerase Inhibitory Activity Using Machine Learning Approaches.

Current topics in medicinal chemistry Jan 1, 2015
Inhibition of non-structural protein 5B (NS5B) represents an attractive strategy for the therapeutic treatment of hepatitis C virus (HCV). In this study, machine learning classifiers such as artificial neural network (ANN), support vector machine (SV...
Machine Learning Drug Design Structure-Activity Relationship Molecular Structure High-Throughput Screening Assays Enzyme Inhibitors Viral Nonstructural Proteins
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Classification models of HCV NS3 protease inhibitors based on support vector machine (SVM).

Combinatorial chemistry & high throughput screening Jan 1, 2015
Inhibition of the hepatitis C virus (HCV) non-structural protein 3 (NS3) serine protease by molecule inhibitors is an attractive strategy for the treatment of hepatitis C. We built four classification models based on a dataset of 413 HCV NS3 protease...
Humans Molecular Docking Simulation Support Vector Machine Hepacivirus Hepatitis C Quantitative Structure-Activity Relationship Viral Nonstructural Proteins Protease Inhibitors Databases, Pharmaceutical
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