AIMC Topic: Voltage-Gated Sodium Channels

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Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2.

The Journal of general physiology
Voltage-gated sodium (NaV) channels are vital regulators of electrical activity in excitable cells. Given their importance in physiology, NaV channels are key therapeutic targets for treating numerous conditions, yet developing subtype-selective drug...

Dendritic computations captured by an effective point neuron model.

Proceedings of the National Academy of Sciences of the United States of America
Complex dendrites in general present formidable challenges to understanding neuronal information processing. To circumvent the difficulty, a prevalent viewpoint simplifies the neuronal morphology as a point representing the soma, and the excitatory a...