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Ion Channel Gating

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ICEPO: the ion channel electrophysiology ontology.

Database : the journal of biological databases and curation 27055825
Ion channels are transmembrane proteins that selectively allow ions to flow across the plasma membrane and play key roles in diverse biological processes. A multitude of diseases, called channelopathies, such as epilepsies, muscle paralysis, pain syn...
Databases as Topic Electrophysiology Gene Ontology Humans Ion Channel Gating Ion Channels Models, Biological Molecular Sequence Annotation Mutation
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Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data.

Communications biology 31925311
Single-molecule research techniques such as patch-clamp electrophysiology deliver unique biological insight by capturing the movement of individual proteins in real time, unobscured by whole-cell ensemble averaging. The critical first step in analysi...
Artificial Intelligence Electrophysiological Phenomena Humans Ion Channel Gating Ion Channels Models, Biological Neural Networks, Computer Patch-Clamp Techniques ROC Curve Single Molecule Imaging Supervised Machine Learning Workflow
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Spatiotemporal identification of druggable binding sites using deep learning.

Communications biology 33110179
Identification of novel protein binding sites expands druggable genome and opens new opportunities for drug discovery. Generally, presence or absence of a binding site depends on the three-dimensional conformation of a protein, making binding site id...
Adenosine Triphosphate Binding Sites Deep Learning Drug Delivery Systems Ion Channel Gating Models, Biological Models, Molecular Protein Binding Protein Conformation Receptors, G-Protein-Coupled Receptors, Purinergic P2X3 Software
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Application of Machine-Learning Methods to Recognize mitoBK Channels from Different Cell Types Based on the Experimental Patch-Clamp Results.

International journal of molecular sciences 33467711
(1) Background: In this work, we focus on the activity of large-conductance voltage- and Ca2+-activated potassium channels (BK) from the inner mitochondrial membrane (mitoBK). The characteristic electrophysiological features of the mitoBK channels ar...
Algorithms Animals Artificial Intelligence Endothelium Female Fibroblasts Hippocampus Ion Channel Gating Kinetics Large-Conductance Calcium-Activated Potassium Channels Machine Learning Mitochondria Neural Networks, Computer Patch-Clamp Techniques Potassium Channels Pregnancy Pregnancy, Animal Protein Conformation Rats Rats, Wistar
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Computational Ion Channel Research: from the Application of Artificial Intelligence to Molecular Dynamics Simulations.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 33656309
Although ion channels are crucial in many physiological processes and constitute an important class of drug targets, much is still unclear about their function and possible malfunctions that lead to diseases. In recent years, computational methods ha...
Animals Artificial Intelligence Binding Sites Humans Ion Channel Gating Ion Channels Ligands Membrane Transport Modulators Models, Molecular Molecular Dynamics Simulation Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Quantitative Structure-Activity Relationship Software Structural Homology, Protein
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Artificial neural network model for predicting changes in ion channel conductance based on cardiac action potential shapes generated via simulation.

Scientific reports 33837240
Many studies have revealed changes in specific protein channels due to physiological causes such as mutation and their effects on action potential duration changes. However, no studies have been conducted to predict the type of protein channel abnorm...
Action Potentials Cardiac Electrophysiology Computer Simulation Ion Channel Gating Ion Channels Machine Learning Myocytes, Cardiac Neural Networks, Computer Neurons Single-Cell Analysis
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Machine Learning Methods for the Analysis of the Patch-Clamp Signals.

Methods in molecular biology (Clifton, N.J.) 38856906
Patch-clamp technique provides a unique possibility to record the ion channels' activity. This method enables tracking the changes in their functional states at controlled conditions on a real-time scale. Kinetic parameters evaluated for the patch-cl...
Animals Humans Ion Channel Gating Ion Channels Machine Learning Patch-Clamp Techniques
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A Deep Learning Approach to Uncover Voltage-Gated Ion Channels' Intermediate States.

The journal of physical chemistry. B 39213618
Owing to recent advancements in cryo-electron microscopy, voltage-gated ion channels have gained a greater comprehension of their structural characteristics. However, a significant enigma remains unsolved for a large majority of these channels: their...
Deep Learning Ion Channel Gating Kv1.2 Potassium Channel Molecular Dynamics Simulation Protein Conformation
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