AIMC Topic: Ion Channel Gating

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A Deep Learning Approach to Uncover Voltage-Gated Ion Channels' Intermediate States.

The journal of physical chemistry. B Aug 30, 2024
Owing to recent advancements in cryo-electron microscopy, voltage-gated ion channels have gained a greater comprehension of their structural characteristics. However, a significant enigma remains unsolved for a large majority of these channels: their...
Protein Conformation Ion Channel Gating Kv1.2 Potassium Channel Deep Learning Molecular Dynamics Simulation
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Artificial neural network model for predicting changes in ion channel conductance based on cardiac action potential shapes generated via simulation.

Scientific reports Apr 9, 2021
Many studies have revealed changes in specific protein channels due to physiological causes such as mutation and their effects on action potential duration changes. However, no studies have been conducted to predict the type of protein channel abnorm...
Single-Cell Analysis Cardiac Electrophysiology Action Potentials Neurons Myocytes, Cardiac Ion Channels Neural Networks, Computer Ion Channel Gating Machine Learning Computer Simulation
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Application of Machine-Learning Methods to Recognize mitoBK Channels from Different Cell Types Based on the Experimental Patch-Clamp Results.

International journal of molecular sciences Jan 15, 2021
(1) Background: In this work, we focus on the activity of large-conductance voltage- and Ca2+-activated potassium channels (BK) from the inner mitochondrial membrane (mitoBK). The characteristic electrophysiological features of the mitoBK channels ar...
Patch-Clamp Techniques Large-Conductance Calcium-Activated Potassium Channels Potassium Channels Endothelium Pregnancy, Animal Ion Channel Gating Hippocampus Protein Conformation Animals Rats, Wistar Rats Fibroblasts Kinetics Mitochondria Neural Networks, Computer Artificial Intelligence Algorithms Machine Learning Pregnancy Female
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Spatiotemporal identification of druggable binding sites using deep learning.

Communications biology Oct 27, 2020
Identification of novel protein binding sites expands druggable genome and opens new opportunities for drug discovery. Generally, presence or absence of a binding site depends on the three-dimensional conformation of a protein, making binding site id...
Models, Biological Adenosine Triphosphate Protein Conformation Binding Sites Ion Channel Gating Receptors, Purinergic P2X3 Protein Binding Receptors, G-Protein-Coupled Software Models, Molecular Drug Delivery Systems Deep Learning
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Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data.

Communications biology Jan 7, 2020
Single-molecule research techniques such as patch-clamp electrophysiology deliver unique biological insight by capturing the movement of individual proteins in real time, unobscured by whole-cell ensemble averaging. The critical first step in analysi...
Humans Neural Networks, Computer Workflow Ion Channel Gating Single Molecule Imaging Models, Biological Artificial Intelligence Patch-Clamp Techniques Ion Channels Supervised Machine Learning ROC Curve Electrophysiological Phenomena
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ICEPO: the ion channel electrophysiology ontology.

Database : the journal of biological databases and curation Apr 7, 2016
Ion channels are transmembrane proteins that selectively allow ions to flow across the plasma membrane and play key roles in diverse biological processes. A multitude of diseases, called channelopathies, such as epilepsies, muscle paralysis, pain syn...
Molecular Sequence Annotation Gene Ontology Ion Channels Models, Biological Humans Ion Channel Gating Databases as Topic Mutation Electrophysiology
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Machine Learning Methods for the Analysis of the Patch-Clamp Signals.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2024
Patch-clamp technique provides a unique possibility to record the ion channels' activity. This method enables tracking the changes in their functional states at controlled conditions on a real-time scale. Kinetic parameters evaluated for the patch-cl...
Animals Ion Channels Ion Channel Gating Humans Machine Learning Patch-Clamp Techniques
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Computational Ion Channel Research: from the Application of Artificial Intelligence to Molecular Dynamics Simulations.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Mar 3, 2021
Although ion channels are crucial in many physiological processes and constitute an important class of drug targets, much is still unclear about their function and possible malfunctions that lead to diseases. In recent years, computational methods ha...
Molecular Dynamics Simulation Ligands Quantitative Structure-Activity Relationship Animals Protein Binding Models, Molecular Ion Channel Gating Structural Homology, Protein Protein Conformation, alpha-Helical Binding Sites Ion Channels Protein Interaction Domains and Motifs Humans Artificial Intelligence Software Protein Conformation, beta-Strand Membrane Transport Modulators
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