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Bioinformatics (Oxford, England)
Apr 28, 2022
MOTIVATION: Exploring drug-protein interactions (DPIs) provides a rapid and precise approach to assist in laboratory experiments for discovering new drugs. Network-based methods usually utilize a drug-protein association network and predict DPIs by t...
Bioinformatics (Oxford, England)
Apr 28, 2022
MOTIVATION: Medical care is becoming more and more specific to patients' needs due to the increased availability of omics data. The application to these data of sophisticated machine learning models, in particular deep learning (DL), can improve the ...
Bioinformatics (Oxford, England)
Apr 28, 2022
MOTIVATION: Deep-learning models, such as convolutional neural networks, are able to accurately map biological sequences to associated functional readouts and properties by learning predictive de novo representations. In silico saturation mutagenesis...
Bioinformatics (Oxford, England)
Apr 28, 2022
MOTIVATION: The development of microscopic imaging techniques enables us to study protein subcellular locations from the tissue level down to the cell level, contributing to the rapid development of image-based protein subcellular location prediction...
Bioinformatics (Oxford, England)
Apr 28, 2022
MOTIVATION: Sequence models based on deep neural networks have achieved state-of-the-art performance on regulatory genomics prediction tasks, such as chromatin accessibility and transcription factor binding. But despite their high accuracy, their con...
Bioinformatics (Oxford, England)
Apr 12, 2022
MOTIVATION: Protein-protein interactions (PPIs) play a key role in diverse biological processes but only a small subset of the interactions has been experimentally identified. Additionally, high-throughput experimental techniques that detect PPIs are...
Bioinformatics (Oxford, England)
Apr 12, 2022
MOTIVATION: Graphs or networks are widely utilized to model the interactions between different entities (e.g. proteins, drugs, etc.) for biomedical applications. Predicting potential interactions/links in biomedical networks is important for understa...
Bioinformatics (Oxford, England)
Apr 12, 2022
MOTIVATION: With the analysis of the characteristic and function of circular RNAs (circRNAs), people have realized that they play a critical role in the diseases. Exploring the relationship between circRNAs and diseases is of far-reaching significanc...
Bioinformatics (Oxford, England)
Apr 12, 2022
MOTIVATION: Kinase-catalyzed phosphorylation of proteins forms the backbone of signal transduction within the cell, enabling the coordination of numerous processes such as the cell cycle, apoptosis, and differentiation. Although on the order of 105 p...
Bioinformatics (Oxford, England)
Apr 12, 2022
MOTIVATION: Protein-RNA interactions play essential roles in many biological processes, including pre-mRNA processing, post-transcriptional gene regulation and RNA degradation. Accurate identification of binding sites on RNA-binding proteins (RBPs) i...