Artificial Intelligence Medical Compendium

Explore the latest research on artificial intelligence and machine learning in medicine.

Showing 4,771 to 4,780 of 203,854 articles

A Foundation Model for the Cancer Genome

bioRxiv
Cancer is a disease of the genome, in which somatic mutations and copy-number alterations determine tumour identity, clinical behaviour, and response to therapy. Consortium-scale sequencing has profiled hundreds of thousands of tumours, yet clinical ... read more 

Ultra-efficient High Resolution 3D Reconstruction of Spatial Omics Data with Neural Transcriptomic Field

bioRxiv
Biological tissues are inherently three-dimensional (3D) ecosystems where spatial architecture dictates cellular function. While spatial omics technologies have revolutionized molecular profiling, they are largely restricted to isolated two-dimension... read more 

Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina

bioRxiv
Comprehensive wiring diagrams from electron microscopy (EM) are a powerful tool to understand the inner workings of the brain. The retina is an easily accessible part of the brain that performs complex visual computations. Its thin, layered structure... read more 

Assessing and Optimizing Low-Frequency Somatic Mutation Detection: A Multi-Platform High-Throughput Sequencing Perspective

bioRxiv
The availability of multiple commercial short-read sequencing platforms necessitates systematic cross-platform performance comparisons, particularly for challenging applications such as low-frequency somatic mutation detection. Here, a large-scale ta... read more 

GeneKnow: AI-powered literature synthesis for gene-context analysis

bioRxiv
Interpreting gene function in specific biological contexts is essential for biomedical research, yet manual literature review is labor-intensive. We developed GeneKnow, a source-grounded framework that uses generative AI models within a controlled hy... read more 

UMITIC: An unsupervised framework for the joint characterization of cellular phenotypes and spatial neighborhoods in multiplex and hyperplex immunofluorescence imaging data

bioRxiv
Multiplexed imaging technologies enable the simultaneous measurement of dozens of protein markers while preserving context, providing a high-resolution view of tissue organization schemes. However, extracting meaningful insights from these high-dimen... read more 

Decoding Cognitive States from fMRI Using Classical Machine Learning and Temporal Dynamics Analysis: An Interpretable Approach Using the Human Connectome Project

bioRxiv
We propose a rigorous and reproducible methodology for analyzing functional MRI data, aimed at: (1) demonstrate their efficiency in classifying task-induced brain states with a limited amount of data, (2) present a methodology to identify brain regio... read more 

Forecasting novel therapeutic development in biomedical research

bioRxiv
Early identification of promising drug research topics is challenging yet crucial for the scientific community to accelerate the development of novel therapeutics. In this work, we leverage large-scale public data from the biomedical literature to ex... read more 

Relationship Extraction for Adverse Drug Events in Clinical Notes Using Large Language Models

medRxiv
Background: Adverse drug events (ADEs) are a critical indicator of patient safety but are often documented only in free-text clinical notes. The potential of recent advances in natural language processing (NLP), particularly generative large language... read more 

Algorithmic Versus Expert Rankings of Large Language Models in Peritoneal Dialysis Prescription Review: A Trap-Embedded Synthetic Benchmark

medRxiv
Background: Clinical LLM benchmarks rarely test whether algorithmic rankings agree with expert clinical judgment. We developed a trap-embedded peritoneal dialysis (PD) benchmark comparing multiple scoring constructs with blinded nephrologist ratings.... read more