Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.

Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University

PMID: 38315381

Abstract

BACKGROUND: Aberrant circular RNA (circRNA) acts as an oncogene or suppressor during neoplasm initiation and development. However, the functions of most circRNAs in osteosarcoma (OS) remain unclear.

Authors

Jiaqi Fan

Department of Orthopaedics, Capital Medical University Affiliated FuXing Hospital, Beijing, China.
Jianhong Liao

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, China.
Yuwen Huang

Department of Gastrointestinal and Hepatology, Beijing Youan Hospital, Capital Medical University, China.

Keywords

ATP-Binding Cassette Transporters Biomarkers, Tumor Bone Neoplasms Chemokine CXCL12 Computational Biology Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans Machine Learning MicroRNAs Osteosarcoma Prognosis Protective Factors RNA, Circular RNA, Competitive Endogenous RNA, Messenger

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View on PubMed Access via DOI PubMed (38315381)

Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.

Abstract

Authors

Keywords

External Resources

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