AIMC Topic: RNA, Competitive Endogenous

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ceRNA regulatory network and immune-neurodegenerative mechanisms of peripheral CD4+ T cells in parkinson's disease.

PloS one Dec 2, 2025
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss and neuroinflammation, with emerging roles of peripheral immune dysregulation in disease progression. This study aimed to investigate the regulatory ne...
Humans Female Parkinson Disease MicroRNAs RNA, Messenger Semaphorins RNA, Competitive Endogenous CD4-Positive T-Lymphocytes Gene Expression Profiling RNA, Long Noncoding Gene Regulatory Networks Case-Control Studies Male Middle Aged Aged
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Noise-Consistent Hypergraph Autoencoder Based on Contrastive Learning for Cancer ceRNA Association Prediction in Complex Biological Regulatory Networks.

Journal of chemical information and modeling Jun 12, 2025
Competitive endogenous RNA (ceRNA) regulatory networks (CENA) have advanced our understanding of noncoding RNAs' roles in complex diseases, providing a theoretical basis for disease mechanisms. Existing ceRNA-disease association prediction methods ar...
Computational Biology Autoencoder Gene Regulatory Networks RNA, Competitive Endogenous Humans Neoplasms Machine Learning
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Machine Learning Gene Signature to Metastatic ccRCC Based on ceRNA Network.

International journal of molecular sciences Apr 11, 2024
Clear-cell renal-cell carcinoma (ccRCC) is a silent-development pathology with a high rate of metastasis in patients. The activity of coding genes in metastatic progression is well known. New studies evaluate the association with non-coding genes, su...
Gene Expression Profiling MicroRNAs Kidney Neoplasms Carcinoma, Renal Cell Machine Learning Neoplasm Metastasis Gene Regulatory Networks Gene Expression Regulation, Neoplastic RNA, Competitive Endogenous Humans Biomarkers, Tumor Transcriptome
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Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University Aug 1, 2024
BACKGROUND: Aberrant circular RNA (circRNA) acts as an oncogene or suppressor during neoplasm initiation and development. However, the functions of most circRNAs in osteosarcoma (OS) remain unclear.
Protective Factors RNA, Competitive Endogenous RNA, Circular Biomarkers, Tumor Computational Biology Gene Regulatory Networks MicroRNAs Machine Learning Gene Expression Regulation, Neoplastic Bone Neoplasms Prognosis Humans Osteosarcoma ATP-Binding Cassette Transporters RNA, Messenger Chemokine CXCL12
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