AIMC Topic: Chemokine CXCL12

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CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches.

PloS one Dec 23, 2024
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Rece...
Extracellular Fluid Nanoparticles Chemokine CXCL12 Rats Receptors, CXCR4 Neoplasm Invasiveness Animals Cell Movement Glioblastoma Cell Line, Tumor Humans Brain Neoplasms
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Construction and evaluation of a metabolic correlation diagnostic model for diabetes based on machine learning algorithms.

Environmental toxicology Apr 29, 2024
BACKGROUND: Diabetes mellitus (DM) is a prevalent chronic disease marked by significant metabolic dysfunctions. Understanding its molecular mechanisms is vital for early diagnosis and treatment strategies.
Chemokine CXCL12 Leukocytes, Mononuclear Diabetes Mellitus Machine Learning Algorithms Humans
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Carbon Dot Blinking Fingerprint Uncovers Native Membrane Receptor Organizations via Deep Learning.

Analytical chemistry Feb 21, 2022
Oligomeric organization of G protein-coupled receptors is proposed to regulate receptor signaling and function, yet rapid and precise identification of the oligomeric status especially for native receptors on a cell membrane remains an outstanding ch...
Benzylamines Cyclams Quantum Dots HeLa Cells Chemokine CXCL12 Receptors, CXCR4 Deep Learning Carbon Humans
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Breast cancer-associated high-order SNP-SNP interaction of CXCL12/CXCR4-related genes by an improved multifactor dimensionality reduction (MDR-ER).

Oncology reports Jul 21, 2016
In association studies, the combined effects of single nucleotide polymorphism (SNP)-SNP interactions and the problem of imbalanced data between cases and controls are frequently ignored. In the present study, we used an improved multifactor dimensio...
Humans Algorithms Breast Neoplasms Genetic Predisposition to Disease Female Epistasis, Genetic Multifactor Dimensionality Reduction Chemokine CXCL12 Receptors, CXCR4 Polymorphism, Single Nucleotide Models, Genetic
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Role of fatty acid metabolism-related genes in periodontitis based on machine learning and bioinformatics analysis.

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Dec 1, 2024
OBJECTIVES: This study aims to investigate the role of genes related to fatty acid metabolism in periodontitis through machine learning and bioinformatics methods.
Machine Learning Algorithms Humans Chemokine CXCL12 Fatty Acids Fatty Acid-Binding Proteins Computational Biology Periodontitis
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Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University Aug 1, 2024
BACKGROUND: Aberrant circular RNA (circRNA) acts as an oncogene or suppressor during neoplasm initiation and development. However, the functions of most circRNAs in osteosarcoma (OS) remain unclear.
Humans Biomarkers, Tumor Gene Regulatory Networks Computational Biology Machine Learning Prognosis RNA, Competitive Endogenous MicroRNAs Chemokine CXCL12 RNA, Circular Protective Factors ATP-Binding Cassette Transporters Osteosarcoma Bone Neoplasms RNA, Messenger Gene Expression Regulation, Neoplastic
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[Naringenin promotes osteogenic differentiation of BMSCs via SDF-1α/CXCR4 signaling axis].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2021
PURPOSE: To explore the influence of naringenin on osteogenic differentiation of bone mesenchymal stem cells(BMSCs), and the role of SDF-1α/CXCR4 signaling axis in the osteogenic differentiation by naringenin.
Cells, Cultured Bone Marrow Cells Rats Flavanones Chemokine CXCL12 Cell Differentiation Receptors, CXCR4 Osteogenesis Animals RNA, Messenger
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