Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies.

Journal: Frontiers in immunology
Published Date: May 8, 2025

Abstract

BACKGROUND: Metabolic dysfunction-associated steatohepatitis (MASH) is becoming increasingly prevalent. Regulated cell death (RCD) has emerged as a significant disease phenotype and may act as a marker for liver fibrosis. The present study aimed to investigate the regulation of RCD-related genes in MASH to elucidate the role of RCD in the progression of MASH.

Authors

  • Zhiqiang Lin
    Health Science Center, East China Normal University, Shanghai, China.
  • Weiyi Li
    Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Yuan Xu
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.
  • Hangchi Liu
    Health Science Center, East China Normal University, Shanghai, China.
  • Yufei Zhang
    School of Computer Science and Technology, Changchun University of Science and Technology, Changchun 130022, China.
  • Ruifen Li
    Health Science Center, East China Normal University, Shanghai, China.
  • Wenqian Zhao
    College of Information Engineering, Yangzhou University, Yangzhou, 225127, China.
  • Youfei Guan
    Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
  • Xiaoyan Zhang
    Institute of Information and Navigation, Air Force Engineering University, Xi'an, Shaanxi, China.

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