BACKGROUND: Staphylococcus aureus (S. aureus) pneumonia constitutes a lethal respiratory infection with persistently high clinical mortality. Although programmed cell death (PCD) pathways are implicated in diverse disease processes, their mechanistic...
Apoptosis : an international journal on programmed cell death
Jan 10, 2026
Autism spectrum disorder (ASD) involves neuroinflammation and dysregulated neuronal death but lacks objective diagnostic biomarkers. This study investigated whether cell death could serve as a molecular basis for ASD diagnosis. We identified cell dea...
BACKGROUND: Hepatic ischemia-reperfusion injury (HIRI) represents the leading cause of postoperative liver dysfunction and failure. Ammonia-induced cell death (ACD), defined by lysosomal and mitochondrial disruption due to intracellular ammonia accum...
Sepsis is a condition resulting from the uncontrolled immune response to infection, leading to widespread inflammatory damage and potentially fatal organ dysfunction. Currently, there is a lack of specific prevention and treatment strategies for seps...
There is a strong relationship between metabolic cell death (MCD) and neurodegenerative diseases. However, the involvement of metabolic cell death (MCD)-related genes (MCDRGs) in Parkinson's disease (PD) pathogenesis remains poorly analyzed. Integrat...
Engineered nanomaterials (ENMs) have gained extensive applications across diverse fields, yet their potential cytotoxicity, particularly toward the immune system, raises significant safety concerns. As critical sentinels of innate immunity, macrophag...
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Immunogenic cell death (ICD) has been implicated in sepsis, a condition with high mortality, through mechanisms involving endoplasmic reticulum stress and other pathophysiological pathways. This study aimed to identify and validate ICD-related biomar...
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
International journal of molecular sciences
Apr 13, 2025
Breast cancer (BRCA) continues to pose a serious risk to women's health worldwide. Neoadjuvant chemotherapy (NAC) is a critical treatment strategy. Nevertheless, the heterogeneity in treatment outcomes necessitates the identification of reliable biom...
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