Clinical Implications of The Cancer Genome Atlas Molecular Classification System in Esophagogastric Cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date:

Abstract

PURPOSE: The Cancer Genome Atlas (TCGA) project defined four distinct molecular subtypes of esophagogastric adenocarcinoma: microsatellite instable (MSI), Epstein-Barr virus (EBV)-associated, genomically stable (GS), and chromosomally instable (CIN). However, an association between molecular subtypes and clinical outcomes has not been clearly demonstrated. Given few actionable biomarkers, we investigated the clinical relevance of TCGA classification system.

Authors

  • Henry S Walch
    Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Raktim Borpatragohain
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Justin Jee
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: jeej@mskcc.org.
  • Waleed Chatila
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Christopher Fong
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA.
  • Steven B Maron
    Memorial Sloan Kettering Cancer Center, New York, NY.
  • Geoffrey Y Ku
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • David H Ilson
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Yelena Y Janjigian
    Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Abraham J Wu
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Pari Shah
    Gastroenterology, Hepatology, and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Daniel G Coit
    Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Manjit S Bains
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Valerie W Rusch
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Bernard J Park
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Matthew J Bott
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Katherine Gray
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • David R Jones
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Michael Berger
    Department of Pediatric Surgery, University Hospital Essen, Essen, Germany.
  • Nikolaus Schultz
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Vivian E Strong
    Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, H-1217, New York, NY 10065, USA. Electronic address: strongv@mskcc.org.
  • Daniela Molena
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Smita Sihag
    Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.