Synthesizing [F]PSMA-1007 PET bone images from CT images with GAN for early detection of prostate cancer bone metastases: a pilot validation study.

Journal: BMC cancer
Published Date: May 21, 2025

Abstract

BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep learning (DL) techniques to synthesize [F]PSMA-1007 PET bone images from CT bone images for the early detection of bone metastases in PCa, which may reduce additional PET/CT scans and relieve the burden on patients.

Authors

  • Liming Chai
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China. chailm@126.com.
  • Xiaolong Yao
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
  • Xiaofeng Yang
    Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
  • Renhua Na
    Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Wei Yan
    State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: yanwei@njau.edu.cn.
  • Mingzheng Jiang
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
  • Haixu Zhu
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
  • Canwen Sun
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
  • Zeqiang Dai
    Department of Nuclear Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
  • Xueying Yang
    South Carolina SmartState Center for Healthcare Quality, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

Keywords

External Resources

Popular Topics
Recent Journals