AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry.

Journal: Circulation. Cardiovascular imaging
Published Date:

Abstract

BACKGROUND: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACEs).

Authors

  • Gudrun M Feuchtner
    Department Radiology, Innsbruck Medical University, 6020 Innsbruck, Austria.
  • Pietro G Lacaita
    Department Radiology, Innsbruck Medical University, 6020 Innsbruck, Austria.
  • Jeroen J Bax
    Departments of Cardiology, Heart Lung Centre, Leiden University Medical Center, Leiden, The Netherlands.
  • Fatima Rodriguez
    From the Division of Cardiovascular Medicine, Cardiovascular Institute (F.R., R.A.H.), Department of Medicine (F.R., R.A.H.).
  • Rine Nakanishi
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.
  • Gianluca Pontone
    Department of Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Saima Mushtaq
    Centro Cardiologico Monzino Scientific Institute for Research, Hospitalisation and Health Care (IRCCS) Milan Italy.
  • Ronny R Buechel
    Department of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland. Electronic address: ronny.buechel@usz.ch.
  • Christoph Gräni
    Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Amit R Patel
    Cardiac Imaging Center, University of Chicago Medical Center, Chicago, Illinois.
  • Cristiane C Singulane
    Division of Cardiovascular Medicine, University of Virginia, Charlottesville (A.R.P., C.C.S.).
  • Andrew D Choi
    Division of Cardiology and Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA adchoi@mfa.gwu.edu.
  • Mouaz Al-Mallah
    Department of Cardiology, Houston Methodist, TX (M.A.-M.,.).
  • Daniele Andreini
    Division of Cardiology and Cardiac Imaging, IRCCS Ospedale Galeazzi - Sant'Ambrogio Milan, Italy.
  • Ronald P Karlsberg
    Division of Cardiology, Cardiovascular Research Foundation of Southern California, Beverly Hills.
  • Geoffrey Cho
    Cardiovascular Research Foundation of Southern California, Cedars-Sinai Heart, David Geffen School of Medicine, University of California Los Angeles (R.P.K., G.C.).
  • Carlos E Rochitte
    Heart Institute, InCor, University of São Paulo Medical School, Brazil (C.E.R.).
  • Mirvat Alasnag
    Cardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.
  • Ashraf Hamdan
    Department of Cardiology, Rabin Medical Center, Petah Tikva and Tel Aviv University, Israel (A.H.).
  • Filippo Cademartiri
    Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy.
  • Erica Maffei
    Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy.
  • Hugo Marques
    UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal.
  • Pedro M Gonçalves Pereira
    UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal (H.M., P.M.G.F).
  • Himanshu Gupta
    Department of Management Studies, Indian Institute of Technology Roorkee, India. Electronic address: himanshuguptadoms@gmail.com.
  • Martin Hadamitzky
    School of Medicine and Health, Institute for Cardiovascular Radiology and Nuclear Medicine, German Heart Center Munich, TUM University Hospital, Technical University of Munich, Munich, Germany.
  • Omar Khalique
    Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian Hospital, New York, New York, USA.
  • Dinesh Kalra
    Division of Cardiology, Rush University Medical Center, Chicago, IL 60612, USA.
  • James D Mills
    Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown (J.D.M.).
  • Nick S Nurmohamed
    Division of Cardiology, The George Washington University School of Medicine, Washington, DC, USA.
  • Paul Knaapen
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Matthew Budoff
    4 Division of Cardiology Los Angeles Biomedical Research at Harbor-UCLA Medical Center Torrance CA.
  • Kashif Shaikh
    University of Tennessee Medical Center, Knoxville (K.S.).
  • Enrico Martin
    Division of Cardiology, MercyOne-Iowa Heart Center, Des Moines, IA (E. Martin).
  • David M German
    Knight Cardiovascular Institute, Oregon Health & Science University, Portland (D.M.G., M.F.).
  • Maros Ferencik
    Knight Cardiovascular Institute, Oregon Health & Science University, Portland (D.M.G., M.F.).
  • Andrew C Oehler
    Allegheny Health Network Cardiovascular Institute, Allegheny Health Network, Pittsburgh, PA (A.C.O.).
  • Roderick Deaño
    Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (R.D.).
  • Prashant Nagpal
    Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Marly van Assen
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Carlo Nicola De Cecco
    Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA (M.V.A., C.N.D.C.).
  • Borek Foldyna
    From the MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Varosmajor St, 1122 Budapest, Hungary (M.K., J.K., B.M., P.M.H.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (J.K., Y.K., A.I., M.T.L., B.F., H.J.A., U.H.); Center for Cause of Death Investigation, Faculty of Medicine, Hokkaido University, Hokkaido, Japan (Y.K.); Department for Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Freiburg, Germany (C.L.S.); and Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (H.J.A.).
  • Jan Michael Brendel
    Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
  • Victor Y Cheng
    Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, USA.
  • Kelley Branch
    Division of Cardiology, Cardiovascular Clinical Trials, University of Washington, Seattle (K.B.).
  • Marcio Bittencourt
    Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (M. Bittencourt).
  • Sabha Bhatti
    National Institute of Cardiovascular Diseases, Karachi, Pakistan (S. Bhatti).
  • Venkateshwar Polsani
    Department of Cardiac Surgery, Piedmont Heart Institute, Atlanta, Ga.
  • George Wesbey
    Advanced Cardiovascular Imaging, Divisions of Cardiology & Radiology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Rhanderson Cardoso
    Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.C., R.B.).
  • Ron Blankstein
    Department of Medicine (Cardiovascular), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Augustin DeLago
    Capitol Cardiology Associates, Albany, NY, USA.
  • Amit Pursnani
    Cardiology, Endeavor NorthShore Cardiovascular Institute, Evanston, IL (A.P.).
  • Amro Alsaid
    Heart Institute, Geisinger, Danville, PA, USA.
  • Stephen Bloom
    Midwest Heart and Vascular Associates, Kansas City, MO (S. Bloom).
  • Vasileios Kamperidis
    Departments of Cardiology, Heart Lung Centre, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece.
  • Fabian Barbieri
    Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum Charite, 10117 Berlin, Germany.
  • Melissa Aquino
    Cleerly Inc, Denver, CO, USA.
  • Ibrahim Danad
    Department of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
  • Alexander van Rosendael
    Dalio Institute of Cardiovascular Imaging, Weill Cornell Medicine, New York, USA.