Integrating single-cell analysis and machine learning to identify COPD hub genes and explore the intervention mechanism of effective component compatibility of Bufei Yishen formula III.

Journal: Journal of ethnopharmacology
Published Date: Jul 24, 2025

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that poses a major threat to public health. Endothelial cells play a critical role in COPD pathogenesis. Recent evidence suggests that the effective-component combination of Bufei Yishen formula III (ECC-BYF III) significantly improves clinical symptoms and quality of life in COPD patients.

Authors

  • Chunlei Liu
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
  • Yange Tian
    Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: yange0910@126.com.
  • Ruilong Lu
    Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: lurl07334@163.com.
  • Changyuan Yue
    Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: cyanyycy@163.com.
  • Yuan Xie
  • Tiantian Zhang
    College of Petroleum and Chemical Engineering, Longdong University, Qingyang, Gansu 745000, China.
  • Jiansheng Li
    Department of Medical Imaging, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, 510095, China. lijiansheng@gzhmu.edu.cn.
  • Qingzhou Guan
    Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: a5410980@163.com.

Keywords

External Resources

Popular Topics
Recent Journals