An FDG-PET-Based Machine Learning Framework to Support Neurologic Decision-Making in Alzheimer Disease and Related Disorders.

Journal: Neurology
Published Date:

Abstract

BACKGROUND AND OBJECTIVES: Distinguishing neurodegenerative diseases is a challenging task requiring neurologic expertise. Clinical decision support systems (CDSSs) powered by machine learning (ML) and artificial intelligence can assist with complex diagnostic tasks by augmenting user capabilities, but workflow integration poses many challenges. We propose that a modeling framework based on fluorodeoxyglucose PET (FDG-PET) imaging can address these challenges and form the basis of an effective CDSS for neurodegenerative disease.

Authors

  • Leland Barnard
    Neurology, Mayo Clinic, Rochester, MN.
  • Hugo Botha
    Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Nick Corriveau-Lecavalier
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Jonathan Graff-Radford
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
  • Ellen Dicks
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Venkatsampath Gogineni
    Neurology, Mayo Clinic, Rochester, MN.
  • Gemeng Zhang
    Biomedical Engineering Department, Tulane University, New Orleans, LA, United States.
  • Brian J Burkett
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Derek R Johnson
    Radiology, Mayo Clinic, Rochester, MN.
  • Sean J Huls
  • Aditya Khurana
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, United States.
  • John L Stricker
    Information Technology, Mayo Clinic, Rochester, MN.
  • Hoon-Ki Paul Min
    Radiology, Mayo Clinic, Rochester, MN.
  • Matthew L Senjem
    Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
  • Winnie Z Fan
    Quantitative Health Science, Mayo Clinic, Rochester, MN.
  • Heather Wiste
    Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
  • Mary M Machulda
    Mayo Clinic, Rochester MN, United States.
  • Melissa E Murray
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Dennis W Dickson
    From the Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Aivi T Nguyen
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
  • R Ross Reichard
    Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • Jeffrey L Gunter
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA. Electronic address: gunter.jeffrey@mayo.edu.
  • Christopher G Schwarz
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
  • Kejal Kantarci
    Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN.
  • Keith Anthony Josephs
    Neurology, Mayo Clinic, Rochester, MN.
  • David S Knopman
    Department of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
  • Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Ronald C Petersen
    Department of Neurology, Mayo Clinic, Rochester, USA.
  • Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
  • Val J Lowe
    Department of Radiology, Mayo Clinic, Rochester, Minnesota.
  • David T Jones
    Department of Computer Science, Bioinformatics Group, University College London, Gower Street, London, WC1E 6BT, United Kingdom. d.t.jones@ucl.ac.uk.