Digital Pathology Quantification of the Continuum of Cirrhosis Severity in Human Liver Biopsies.

Journal: Liver international : official journal of the International Association for the Study of the Liver
Published Date: Jul 1, 2025

Abstract

BACKGROUND AND AIMS: Liver biopsy is the gold standard for assessing fibrosis in cirrhotic livers, yet cirrhosis is spatially heterogeneous and continuously remodels. This study evaluates a novel phenotypic digital pathology platform for continuous fibrosis severity quantification and sensitivity to sampling variability.

Authors

  • Louis Petitjean
    PharmaNest, Princeton, NJ, USA.
  • Li Chen
    Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University, Jinan, China.
  • Xiaofei Zhang
  • Thomas Schiano
    Division of Liver Diseases, Department of Medicine, Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Mathieu Petitjean
    PharmaNest, Princeton, NJ, USA.
  • Arun J Sanyal
    Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
  • MariaIsabel Fiel
    Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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