Machine Learning Algorithms in Controlled Donation After Circulatory Death Under Normothermic Regional Perfusion: A Graft Survival Prediction Model.

Journal: Transplantation
Published Date: Jan 9, 2025

Abstract

BACKGROUND: Several scores have been developed to stratify the risk of graft loss in controlled donation after circulatory death (cDCD). However, their performance is unsatisfactory in the Spanish population, where most cDCD livers are recovered using normothermic regional perfusion (NRP). Consequently, we explored the role of different machine learning-based classifiers as predictive models for graft survival. A risk stratification score integrated with the model of end-stage liver disease score in a donor-recipient (D-R) matching system was developed.

Authors

  • Rafael Calleja
    Hepatobiliary Surgery and Liver Transplantation Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Hospital Universitario Reina Sofía, University of Córdoba, Córdoba, Spain.
  • Marcos Rivera
    Department of Computational Sciences and Numerical Analysis, University of Córdoba, Córdoba, Spain.
  • David Guijo-Rubio
    Departamento de Informática y Análisis Numérico, Universidad de Córdoba, Córdoba, España.
  • Amelia J Hessheimer
    General and Digestive Surgery Department, Hospital Universitario La Paz, Madrid, Spain.
  • Gloria de la Rosa
    Organización Nacional de Trasplantes, Madrid, Spain.
  • Mikel Gastaca
    Hepatobiliary Surgery and Liver Transplantation Unit, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Bilbao, Spain.
  • Alejandra Otero
    General and Digestive Surgery Department, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain.
  • Pablo Ramírez
    Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de La Arrixaca, IMIB-ARRIXACA, El Palmar, Murcia, Spain.
  • Andrea Boscà-Robledo
    General and Digestive Surgery Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Julio Santoyo
    General and Digestive Surgery Department, Hospital Regional Universitario de Málaga, Spain.
  • Luis Miguel Marín Gómez
    General and Digestive Surgery Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
  • Jesús Villar Del Moral
    General and Digestive Surgery Department, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
  • Yiliam Fundora
    Division of Hepatobiliary and General Surgery, Department of Surgery, Institut de Malalties Digestives I Metabòliques (IMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
  • Laura Lladó
    General and Digestive Surgery Department, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Spain.
  • Carmelo Loinaz
    General and Digestive Surgery Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Manuel C Jiménez-Garrido
    General and Digestive Surgery Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
  • Gonzalo Rodríguez-Laíz
    General and Digestive Surgery Department, Hospital General Universitario de Alicante, Alicante, Spain.
  • José Á López-Baena
    General and Digestive Surgery Department, Hospital General Universitario Gregorio Marañón General University Hospital, Madrid, Spain.
  • Ramón Charco
    General and Digestive Surgery Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
  • Evaristo Varo
    General and Digestive Surgery Department, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
  • Fernando Rotellar
    Department of General Surgery, School of Medicine, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.
  • Ayaya Alonso
    General and Digestive Surgery Department, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
  • Juan C Rodríguez-Sanjuan
    General and Digestive Surgery Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  • Gerardo Blanco
    General and Digestive Surgery Department, Hospital Universitario Infanta Cristina, Badajoz, Spain.
  • Javier Nuño
    General and Digestive Surgery Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • David Pacheco
    General and Digestive Surgery Department, Hospital Universitario Río Hortega, Valladolid, Spain.
  • Elisabeth Coll
    Organización Nacional de Trasplantes, Madrid, Spain.
  • Beatriz Domínguez-Gil
    Organización Nacional de Trasplantes, Madrid, Spain.
  • Constantino Fondevila
    General and Digestive Surgery Department, Hospital Universitario La Paz, Madrid, Spain.
  • María Dolores Ayllón
    Unit of Hepatobiliary Surgery and Liver Transplantation, Córdoba, Spain.
  • Manuel Durán
    Hepatobiliary Surgery and Liver Transplantation Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Hospital Universitario Reina Sofía, University of Córdoba, Córdoba, Spain.
  • Rubén Ciria
    Liver Transplantation Unit, Reina Sofía Hospital, Av. Menéndez Pidal, 14004 Córdoba, Spain.
  • Pedro A Gutiérrez
    Department of Computer Science and Numerical Analysis, University of Córdoba, Campus Universitario de Rabanales, "Albert Einstein Building", Third Floor, 14071 Córdoba, Spain.
  • Antonio Gómez-Orellana
    Department of Computational Sciences and Numerical Analysis, University of Córdoba, Córdoba, Spain.
  • César Hervás-Martínez
    Department of Computer Science and Numerical Analysis, University of Córdoba, Campus Universitario de Rabanales, "Albert Einstein Building", Third Floor, 14071 Córdoba, Spain.
  • Javier Briceño
    Liver Transplantation Unit, Reina Sofía Hospital, Av. Menéndez Pidal, 14004 Córdoba, Spain.

Keywords

External Resources

Popular Topics
Recent Journals