Combined peritumoral radiomics and clinical features predict 12-month progression free survival in glioblastoma.

Journal: Journal of neuro-oncology
Published Date:

Abstract

PURPOSE: Analyzing post-treatment MRIs from glioblastoma patients can be challenging due to similar radiological presentations of disease progression and treatment effects. Identifying radiomics features (RFs) revealing progressive glioblastoma can contribute to an improved evaluation of the response assessment.

Authors

  • Yeong Chul Yun
    Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany. YeongChul.Yun@med.uni-heidelberg.de.
  • Johann M E Jende
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Freya Garhöfer
    Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany.
  • Sabine Wolf
    Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany.
  • Katharina Holz
    Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany.
  • Anja Hohmann
    Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Philipp Vollmuth
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: philipp.vollmuth@med.uni-heidelberg.de.
  • Martin Bendszus
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Heinz-Peter Schlemmer
    From the Department of Radiology (D.B., P.S., J.P.R., P.K., K.Y., M.F., H.P.S.), Division of Medical Image Computing (S.K., M.G., N.G., K.H.M.H.), Division of Statistics (M.W.), and Department of Medical Physics (T.A.K., F.D.), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany (D.B., H.P.S., K.H.M.H.); and Departments of Urology (J.P.R., B.H., M.H., B.A.H.) and Neuroradiology (P.K.), University of Heidelberg Medical Center, Heidelberg, Germany.
  • Felix Sahm
    Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sabine Heiland
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Wolfgang Wick
    Neurology Clinic, Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Varun Venkataramani
    Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Felix T Kurz
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.