AIMC Topic: Progression-Free Survival
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Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.
BMC cancer
May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Aromatase Inhibitors
Aminopyridines
Protein Kinase Inhibitors
Benzimidazoles
Treatment Outcome
Receptors, Estrogen
Humans
Purines
Randomized Controlled Trials as Topic
Female
Receptors, Progesterone
Progression-Free Survival
Breast Neoplasms
Cyclin-Dependent Kinase 4
Receptor, ErbB-2
Antineoplastic Combined Chemotherapy Protocols
Cyclin-Dependent Kinase 6
Network Meta-Analysis as Topic
Utilizing explainable machine learning for progression-free survival prediction in high-grade serous ovarian cancer: insights from a prospective cohort study.
International journal of surgery (London, England)
May 1, 2025
BACKGROUND: High-grade serous ovarian cancer (HGSOC) remains one of the most challenging gynecological malignancies, with over 70% of ovarian cancer patients ultimately experiencing disease progression. The current prognostic tools for progression-fr...
Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer.
Oncogene
Feb 26, 2025
CDK4/6 inhibitors in combination with endocrine therapy are widely used to treat HR+/HER2- metastatic breast cancer leading to improved progression-free survival (PFS) compared to single agent endocrine therapy. Over 300 patients receiving standard-o...
Progression-Free Survival Prediction Performance of ChatGPT: Analysis With Real Life Data in Early and Locally Advanced Prostate Cancer.
The Prostate
Feb 13, 2025
OBJECTIVE: To evaluate the progression-free survival (PFS) time in patients with early-stage and locally advanced prostate cancer and to compare the estimates provided by ChatGPT with actual survival data.
Harnessing Machine Learning and Nomogram Models to Aid in Predicting Progression-Free Survival for Gastric Cancer Patients Post-Gastrectomy with Deficient Mismatch Repair(dMMR).
BMC cancer
Jan 24, 2025
OBJECTIVE: To assess the effectiveness of a machine learning framework and nomogram in predicting progression-free survival (PFS) post-radical gastrectomy in patients with dMMR.
Explainable PET-Based Habitat and Peritumoral Machine Learning Model for Predicting Progression-free Survival in Clinical Stage IA Pure-Solid Non-small Cell Lung Cancer: A Two-center Study.
Academic radiology
Jan 4, 2025
RATIONALE AND OBJECTIVES: This study aimed to develop and validate machine learning (ML) models utilizing positron emission tomography (PET)-habitat of the tumor and its peritumoral microenvironment to predict progression-free survival (PFS) in patie...
Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.
Nature communications
Jan 2, 2025
Pediatric low-grade gliomas (pLGGs) exhibit heterogeneous prognoses and variable responses to treatment, leading to tumor progression and adverse outcomes in cases where complete resection is unachievable. Early prediction of treatment responsiveness...
Predicting benefit from PARP inhibitors using deep learning on H&E-stained ovarian cancer slides.
European journal of cancer (Oxford, England : 1990)
Dec 26, 2024
PURPOSE: Ovarian cancer patients with a Homologous Recombination Deficiency (HRD) often benefit from polyadenosine diphosphate-ribose polymerase (PARP) inhibitor maintenance therapy after response to platinum-based chemotherapy. HR status is currentl...
Prognostic models for progression-free survival in atypical meningioma: Comparison of machine learning-based approach and the COX model in an Asian multicenter study.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Dec 19, 2024
BACKGROUND AND PURPOSE: Atypical meningiomas are prevalent intracranial tumors with varied prognoses and recurrence rates. The role of adjuvant radiotherapy (ART) in atypical meningiomas remains debated. This study aimed to develop and validate a pro...
Predicting progression-free survival in sarcoma using MRI-based automatic segmentation models and radiomics nomograms: a preliminary multicenter study.
Skeletal radiology
Dec 4, 2024
OBJECTIVES: Some sarcomas are highly malignant, associated with high recurrence despite treatment. This multicenter study aimed to develop and validate a radiomics signature to estimate sarcoma progression-free survival (PFS).
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