Plasma Proteomic Profiles Predict Individual Future Osteoarthritis Risk.

Journal: Arthritis & rheumatology (Hoboken, N.J.)
Published Date: Mar 20, 2025

Abstract

OBJECTIVE: Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during the initial phases and accurate biomarkers. This study aims to identify plasma proteins associated with future risk of OA and develop a predictive model.

Authors

  • Zijian Kang
  • Jianzheng Zhang
    The Fourth Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
  • Wenxin Liu
    School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang P. R. China.
  • Chen Zhu
    Chongqing Institute for Food and Drug Control, Chongqing 401121, China.
  • Ying Zhu
    China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Ping Li
    Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Kai Li
    Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
  • Qiang Tong
    Sony Research and Development Center Beijing Lab, Chao-Yang District, Beijing, 100027, China.
  • Sheng-Ming Dai
    Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

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