Machine learning based differential diagnosis of schizophrenia, major depression disorder and bipolar disorder using structural magnetic resonance imaging.

Journal: Journal of affective disorders
Published Date:

Abstract

BACKGROUND: Cortical morphological abnormalities in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) have been identified in past research. However, their potential as objective biomarkers to differentiate these disorders remains uncertain. Machine learning models may offer a novel diagnostic tool.

Authors

  • Peiyu Cao
    Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, China.
  • Runda Li
    Vanderbilt University, 2301 Vanderbilt Place, Nashville, 37235, TN, USA. Runda.li@vanderbilt.edu.
  • Yuting Li
    Department of Food Science and Nutrition, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China.
  • Yingbo Dong
    Huai'an No. 3 People's Hospital, China.
  • Yilin Tang
    Radiology Department, Huadong Hospital, Affiliated with Fudan University, Shanghai, China.
  • Guoxin Xu
    Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, China.
  • Qi Si
    College of Mathematics and Systems Science, Xinjiang University, Urumuqi 830046, China; Institute of Mathematics and Physics, Xinjiang University, Urumuqi 830046, China.
  • Congxin Chen
    Nanjing Drum Tower Hospital, China.
  • Lijun Chen
    Department of Obstetrics and Gynecology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan Shandong China.
  • Wen Liu
    Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
  • Ye Yao
    Department of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, China.
  • Yuxiu Sui
    Department of Psychiatry, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Jiulou Zhang