Circulating proteins and metabolites panel for noninvasive preoperative diagnosis of epithelial ovarian cancer.

Journal: BMC medicine
Published Date:

Abstract

BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker candidates for noninvasive diagnosis and differential diagnosis.

Authors

  • Yan Jia
    Department of Gastroenterology, the 7Medical Center of PLA General Hospital, Beijing, China.
  • Li Yuan
    Research Institute of Natural Gas Technology, Petro China Southwest Oil and Gas Field Company, Chengdu, 610213, China.
  • Weijia Wen
    Advanced Materials Thrust, Department of Physics, Hong Kong University of Science and Technology, Guangzhou, 511458, China. phwen@ust.hk.
  • Linna Chen
    Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
  • Xueyuan Zhao
    Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
  • Qiong Wu
    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, P. R. China.
  • Yan Liao
    Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
  • Caixia Shao
    Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
  • Chaoyun Pan
    Department of Biochemistry and Molecular Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. panchy27@mail.sysu.edu.cn.
  • Chunyu Zhang
    Department of Neurosurgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Shuzhong Yao
    Department of Obstetrics and Gynecology, Precision Medicine Institute, Sun Yat-sen University, Yuexiu, Guangzhou, Guangdong, China.