The correlation of liquid biopsy genomic data to radiomics in colon, pancreatic, lung and prostatic cancer patients.

Journal: European journal of cancer (Oxford, England : 1990)
Published Date: Jul 8, 2025

Abstract

INTRODUCTION: With the advances in artificial intelligence (AI) and precision medicine, radiomics has emerged as a promising tool in the field of oncology. Radiogenomics integrates radiomics with genomic data, potentially offering a non-invasive method for identifying biomarkers relevant to cancer therapy. Liquid biopsy (LB) has further revolutionized cancer diagnostics by detecting circulating tumor DNA (ctDNA), enabling real-time molecular profiling. This study explores the integration of radiomics and LB to predict genomic alterations in solid tumors, including lung, colon, pancreatic, and prostate cancers.

Authors

  • Antoine Italiano
    University of Bordeaux, 33000, Bordeaux, France.
  • Othilie Gautier
    Laboratoire d'Imagerie Biomedicale Multimodale Paris-Saclay (BioMAPS), Université Paris-Saclay, Inserm, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, Villejuif 94800, France.
  • Jules Dupont
    Laboratoire d'Imagerie Biomedicale Multimodale Paris-Saclay (BioMAPS), Université Paris-Saclay, Inserm, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, Villejuif 94800, France; Département d'Imagerie, Gustave Roussy, Université Paris Saclay, 114 Rue Edouard Vaillant, Villejuif 94805, France.
  • Tarek Assi
    Division of International Patients Care, Gustave Roussy, 94805, Villejuif, France.
  • Lama Dawi
    Department of Radiology, Gustave Roussy, 94805 Villejuif, France.
  • Littisha Lawrance
    Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay. BIOMAPS, UMR 1281. Université Paris-Saclay, Inserm, CNRS, CEA, 94800 Villejuif, France.
  • Alexandre Bône
    Guerbet Research, Villepinte.
  • Ghina Jardali
    Laboratoire d'Imagerie Biomedicale Multimodale Paris-Saclay (BioMAPS), Université Paris-Saclay, Inserm, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, Villejuif 94800, France; Département d'Imagerie, Gustave Roussy, Université Paris Saclay, 114 Rue Edouard Vaillant, Villejuif 94805, France.
  • Aurélie Choucair
    Department of Radiology, Gustave Roussy, Villejuif, France.
  • Samy Ammari
    Service de Radiologie, Gustave-Roussy, Université Paris-Saclay, Villejuif, France.
  • Arnaud Bayle
    Bureau biostatistique et epidémiologie, Gustave-Roussy, université Paris-Saclay, 94800 Villejuif, France; Inserm, CESP U1018 Oncostat, labelisé Ligue contre le cancer, université Paris-Saclay, 94800 Villejuif, France.
  • Etienne Rouleau
    Département de Biopath, Gustave Roussy Université Paris-Saclay, Villejuif, France.
  • Paul Henry Cournede
    Université Paris-Saclay, Villejuif, France; CentraleSupelec, Département de la recherche, Gif Sur Yvette, France.
  • Isabelle Borget
    Gustave Roussy Cancer Campus, Villejuif, France.
  • Benjamin Besse
    University Paris-Saclay, Gif-sur-Yvette, France.
  • Fabrice Barlesi
    Département d'Oncologie Médicale, Gustave Roussy, Université Paris-Saclay, Villejuif, 94805, France.
  • Christophe Massard
    Gustave Roussy Cancer Campus, Villejuif, France.
  • Nathalie Lassau
    Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, BIOMAPS, UMR 1281, Université Paris-Saclay, Inserm, CNRS, CEA, 94800 Villejuif, France; Department of Imaging, Institut Gustave Roussy, Université Paris-Saclay. 94800 Villejuif, France.

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